(1R,2S)-1-phenyl-2-[((1R)-phenylethyl)amino]-1-propanol

Base Information

• Chemical Name: (1R,2S)-1-phenyl-2-[((1R)-phenylethyl)amino]-1-propanol
• CAS No.: 154170-05-5
• Molecular Formula: C₁₇H₂₁NO
• Molecular Weight: 255.36
• Mol file: 154170-05-5.mol

Synonyms:(1R,2S)-1-phenyl-2-[((1R)-phenylethyl)amino]-1-propanol

Chemical Property of (1R,2S)-1-phenyl-2-[((1R)-phenylethyl)amino]-1-propanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1R,2S)-1-phenyl-2-[((1R)-phenylethyl)amino]-1-propanol

There total 13 articles about (1R,2S)-1-phenyl-2-[((1R)-phenylethyl)amino]-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(2S)-1-phenyl-2-[((1R)-phenylethyl)amino]-1-propanone methanesulfonate (635304-48-2) → (1R,2S)-1-phenyl-2-[((1R)-phenylethyl)amino]-1-propanol (154170-05-5)

Guidance literature:

(2S)-1-phenyl-2-[((1R)-phenylethyl)amino]-1-propanone methanesulfonate; With sodium tetrahydroborate; In ethanol; at 15 ℃; for 1h;

With hydrogenchloride; In ethanol; water;

With sodium hydroxide; In ethanol; water; ethyl acetate; Product distribution / selectivity;

Reference yield: 84.0%

(R)-phenyl{(S)-1-[(R)-1-phenylethyl]aziridin-2-yl}methanol (180323-00-6) → (1R,2S)-1-phenyl-2-[((1R)-phenylethyl)amino]-1-propanol (154170-05-5)

Guidance literature:

With hydrogen; palladium dihydroxide; In ethyl acetate; Ambient temperature;

DOI:10.1021/jo9603183

Reference yield:

(1R,2S)-1-Phenyl-2-[1-phenyl-eth-(E)-ylideneamino]-propan-1-ol → (1R,2S)-1-phenyl-2-[((1R)-phenylethyl)amino]-1-propanol (154170-05-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In isopropyl alcohol; at 0 - 10 ℃; under 2068.65 - 2585.81 Torr;

DOI:10.1016/j.bmcl.2014.05.027

upstream raw materials:

(R)-phenyl{(S)-1-[(R)-1-phenylethyl]aziridin-2-yl}methanol

bromobenzene

N-<(R)-(+)-α-methylbenzyl>aziridine-2(S)-methanol

(2S)-1-[(1R)-1-phenylethyl]aziridine-2-carbaldehyde

Downstream raw materials:

(1R,2S)-norephedrine

(1R,2S,1'R)-(-)-2-(1'-phenylethylamino)-1-phenyl-1-propanol hydrochloride

Refernces

• 1、 -. "PROCESS FOR PRODUCING OPTICALLY ACTIVE s-AMINO ALCOHOL". Page/Page column 24. . Retrieved 2008/06/13.
• 2、 Hwang, Gwon-Il,Chung, Jae-Ho,Lee, Won Koo. "Efficient synthesis of Ephedra alkaloid analogues using an enantiomerically pure N-[(R)-(+)-α-methylbenzyl]aziridine-2-carboxaldehyde". . p. 6183 - 6188. Retrieved 2007/10/03.