Etofenamate

Base Information

• Chemical Name: Etofenamate
• CAS No.: 30544-47-9
• Molecular Formula: C18H18 F3 N O4
• Molecular Weight: 369.34
• Hs Code.: 2922509090
• European Community (EC) Number: 250-231-8
• UNII: KZF0XM66JC
• DSSTox Substance ID: DTXSID2045448
• Nikkaji Number: J20.314I
• Wikipedia: Etofenamate
• Wikidata: Q414378
• NCI Thesaurus Code: C80545
• Pharos Ligand ID: MB9Y9K4MQFC3
• Metabolomics Workbench ID: 152058
• ChEMBL ID: CHEMBL1451633
• Mol file: 30544-47-9.mol

Synonyms:Anthranilicacid, N-(a,a,a-trifluoro-m-tolyl)-, 2-(2-hydroxyethoxy)ethyl ester (8CI);2-(2-Hydroxyethoxy)ethyl flufenamate;2-[[3-(Trifluoromethyl)phenyl]amino]benzoic acid 2-(2-hydroxyethoxy)ethylester; B 577; Bay-d 1107; Bayrogel; Etofenamate; Glasel; Reumon; Rheumon;Rheumon gel; TV 485; Traumon Gel; WHR 5020

Chemical Property of Etofenamate

Chemical Property:

• Vapor Pressure: 6.34E-09mmHg at 25°C
• Melting Point: 25°C
• Refractive Index: nD25 1.564
• Boiling Point: 451.1°C at 760 mmHg
• PKA: 14.32±0.10(Predicted)
• Flash Point: 226.6°C
• PSA: 67.79000
• Density: 1.317g/cm³
• LogP: 3.68770
• Storage Temp.: Refrigerator
• Solubility.: Practically insoluble in water, miscible with ethanol (96 per cent) and with ethyl acetate.
• XLogP3: 4.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 9
• Exact Mass: 369.11879254
• Heavy Atom Count: 26
• Complexity: 433

Purity/Quality:

99% ^*data from raw suppliers

Etofenamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(=O)OCCOCCO)NC2=CC=CC(=C2)C(F)(F)F
• Recent EU Clinical Trials: Randomized, controlled, multi-center trial to evaluate the efficacy and safety of Lixim 70 mg wirkstoffhaltiges Pflaster (etofenamate 70 mg medicated plaster) vs. placebo in the local symptomatic and short-term treatment of pain in acute strains, sprains or bruises of soft tissues following blunt trauma, e.g. sports injuries
• Uses: Medication used to alleviate joint and muscle pain. anti-inflammatory;cyclooxygenase inhibitor As a histamine H1 -receptor antagonist, Etofenamate can be used as anti-inflammatory;cyclooxygenase inhibitor and medication used to alleviate joint and muscle pain.
• Therapeutic Function: Antiinflammatory

Technology Process of Etofenamate

There total 6 articles about Etofenamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ etofenamate (30544-47-9) + oleic acid decyl ester (3687-46-5)

Guidance literature:

Reference yield:

2-(3-Trifluoromethyl-phenylamino)-benzoic acid 2-(2-benzyloxy-ethoxy)-ethyl ester (64352-85-8) → etofenamate (30544-47-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; ethyl acetate;

Reference yield:

C43H40F6N2O8 (64661-77-4) → etofenamate (30544-47-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

upstream raw materials:

2-(3-Trifluoromethyl-phenylamino)-benzoic acid 2-(2-benzyloxy-ethoxy)-ethyl ester

C₄₃H₄₀F₆N₂O₈

2-(2-Chloroethoxy)ethanol

Refernces

• 1、 -. "Isobutylene polymer active compound release systems". . . Retrieved 2008/06/13.