Technology Process of methyl 6-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)nicotinate
There total 1 articles about methyl 6-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)nicotinate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
toluene-4-sulfonic acid;
In
dichloromethane;
at 20 ℃;
for 42h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: diisobutylaluminium hydride / tetrahydrofuran; hexane / 1.5 h / 0 - 20 °C
2: di-isopropyl azodicarboxylate; tricyclohexylphosphine / tetrahydrofuran / 20 °C
With
di-isopropyl azodicarboxylate; diisobutylaluminium hydride; tricyclohexylphosphine;
In
tetrahydrofuran; hexane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: diisobutylaluminium hydride / tetrahydrofuran; hexane / 1.5 h / 0 - 20 °C
2: di-isopropyl azodicarboxylate; tricyclohexylphosphine / tetrahydrofuran / 20 °C
3: dimethylaminoacetic acid; copper(l) iodide; caesium carbonate / 1,4-dioxane / 48 h / 110 °C / Sealed tube
With
copper(l) iodide; dimethylaminoacetic acid; di-isopropyl azodicarboxylate; diisobutylaluminium hydride; caesium carbonate; tricyclohexylphosphine;
In
tetrahydrofuran; 1,4-dioxane; hexane;