Buformin

Base Information

• Chemical Name: Buformin
• CAS No.: 692-13-7
• Molecular Formula: C6H15 N5
• Molecular Weight: 157.219
• European Community (EC) Number: 211-726-4
• UNII: W2115E9C7B
• DSSTox Substance ID: DTXSID6046420
• Nikkaji Number: J9.453F
• Wikipedia: Buformin
• Wikidata: Q715104
• NCI Thesaurus Code: C95328
• Metabolomics Workbench ID: 67432
• ChEMBL ID: CHEMBL39736
• Mol file: 692-13-7.mol

Synonyms:1 Butylbiguanide;1-Butylbiguanide;Adebit;Buformin;Butylbiguanide;Gliporal;Retard, Silubin;Silubin;Silubin Retard

Chemical Property of Buformin

Chemical Property:

• Vapor Pressure: 0.000275mmHg at 25°C
• Refractive Index: 1.8070 (estimate)
• Boiling Point: 322.7°C at 760 mmHg
• Flash Point: 148.9°C
• PSA: 97.78000
• Density: 1.22g/cm³
• LogP: 1.47550
• XLogP3: -0.6
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 157.13274550
• Heavy Atom Count: 11
• Complexity: 156

Purity/Quality:

98%Min ^*data from raw suppliers

Buformin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCN=C(N)N=C(N)N
• Uses: Buformin, clinically used for diabetes mellitus, is known to improve resistance to insulin in patients. It suppresses the expression of glyceraldehyde 3-phosphate dehydrogenase

Technology Process of Buformin

There total 4 articles about Buformin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-butylamine (109-73-9,85404-21-3) + N-Cyanoguanidine (127099-85-8,780722-26-1,461-58-5) → buformin (692-13-7)

Guidance literature:

With copper(II) sulfate;

Reference yield:

n-butylamine hydrochloride (3858-78-4) + N-Cyanoguanidine (127099-85-8,780722-26-1,461-58-5) → buformin (692-13-7)

Guidance literature:

DOI:10.1021/jo01093a619 DOI:10.1021/ja01523a059

Reference yield:

N-Cyanoguanidine (127099-85-8,780722-26-1,461-58-5) → buformin (692-13-7)

Guidance literature:

at 160 ℃;

upstream raw materials:

n-butylamine hydrochloride

N-Cyanoguanidine

N-butylamine

Downstream raw materials:

N-butyl-[1,3,5]triazine-2,4-diamine

Refernces