benzyl L-2-benzyloxycarbonylamino-5-diazo-4-oxopentanoate

Base Information

• Chemical Name: benzyl L-2-benzyloxycarbonylamino-5-diazo-4-oxopentanoate
• CAS No.: 50930-59-1
• Molecular Formula: C₂₀H₁₉N₃O₅
• Molecular Weight: 381.388
• Mol file: 50930-59-1.mol

Synonyms:benzyl L-2-benzyloxycarbonylamino-5-diazo-4-oxopentanoate

Chemical Property of benzyl L-2-benzyloxycarbonylamino-5-diazo-4-oxopentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl L-2-benzyloxycarbonylamino-5-diazo-4-oxopentanoate

There total 3 articles about benzyl L-2-benzyloxycarbonylamino-5-diazo-4-oxopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Z-Asp-OBn (4779-31-1) → benzyl L-2-benzyloxycarbonylamino-5-diazo-4-oxopentanoate (50930-59-1)

Guidance literature:

With diethyl ether; phosphorus pentachloride; Behandeln des Reaktionsprodukts mit Diazomethan in Aether;

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + N-(benzyloxycarbonyl)-L-aspartic acid-4-chloride-1-benzyl ester (64578-11-6) → benzyl L-2-benzyloxycarbonylamino-5-diazo-4-oxopentanoate (50930-59-1)

Guidance literature:

In diethyl ether; at -78 ℃; for 12h; Yield given;

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + (S)-2-Benzyloxycarbonylamino-4-isobutoxycarbonyloxy-4-oxo-butyric acid benzyl ester → benzyl L-2-benzyloxycarbonylamino-5-diazo-4-oxopentanoate (50930-59-1)

Guidance literature:

In diethyl ether; for 16h; Ambient temperature;

upstream raw materials:

Z-Asp-OBn

diazomethane

N-(benzyloxycarbonyl)-L-aspartic acid-4-chloride-1-benzyl ester

Downstream raw materials:

4-oxo-L-norvaline

(S)-3-(2-Amino-thiazol-4-yl)-2-benzyloxycarbonylamino-propionic acid benzyl ester

(2S)-2-amino-3-(2-mercapto-1H-imidazol-4-yl)propanoic acid

L-histidine

Refernces

• 1、 Patt, William C.,Skeean, Richard W.,Steinbaugh, Bruce A.. "Synthesis of Enantiomerically Pure Amino Acids Containing a 2-Amino-4-thiazolyl Side Chain". . p. 3097 - 3102. Retrieved 2007/10/02.