3,3,5,5-TETRAMETHYL-1-PYRROLINE N-OXIDE

Base Information

• Chemical Name: 3,3,5,5-TETRAMETHYL-1-PYRROLINE N-OXIDE
• CAS No.: 10135-38-3
• Molecular Formula: C₈H₁₅NO
• Molecular Weight: 141.213
• Hs Code.: 29339980
• Mol file: 10135-38-3.mol

Synonyms:1-Pyrroline,3,3,5,5-tetramethyl-, 1-oxide (6CI,7CI,8CI);3,3,5,5-Tetramethyl-1-pyrroline1-oxide;NSC 78027;3, 3, 5, 5-Tetramethyl-pyrroline-N-oxide;

Chemical Property of 3,3,5,5-TETRAMETHYL-1-PYRROLINE N-OXIDE

Chemical Property:

• Appearance/Colour: white to light yellow adhering crystalline chunks
• Vapor Pressure: 0.0332mmHg at 25°C
• Melting Point: 58-61 °C (lit.)
• Refractive Index: 1.475
• Boiling Point: 251 °C at 760 mmHg
• PKA: 2.50±0.60(Predicted)
• Flash Point: 113.3 °C
• PSA: 28.75000
• Density: 0.93 g/cm³
• LogP: 1.73480
• Storage Temp.: 0-6°C

Purity/Quality:

99% ^*data from raw suppliers

TMPO ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: TMPO is a pyrroline-based N-oxyl spin trap. TMPO is described for use as a cell-permeable spin trap probe for ESR studies of biological systems.

Technology Process of 3,3,5,5-TETRAMETHYL-1-PYRROLINE N-OXIDE

There total 3 articles about 3,3,5,5-TETRAMETHYL-1-PYRROLINE N-OXIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-Hydroxy-2,2,4,4-tetramethylpyrrolidine (10135-40-7) → 3,4-dihydro-2,2,4,4-tetrametyl pyrrole-1-oxide (10135-38-3)

Guidance literature:

With ammonium hydroxide; air; copper diacetate;

Reference yield:

2,4,4-trimethyl-1-pyrroline N-oxide (6931-11-9) → 3,4-dihydro-2,2,4,4-tetrametyl pyrrole-1-oxide (10135-38-3)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether / anschliessenden Behandeln mit wss. Ammoniumchlorid-Loesung

2: aq.-ethanolic ammonia; copper (II)-acetate; air

With ammonium hydroxide; air; diethyl ether; copper diacetate;

Reference yield:

4,4-dimethyl-5-nitropentan-2-one (35223-73-5) → 3,4-dihydro-2,2,4,4-tetrametyl pyrrole-1-oxide (10135-38-3)

Guidance literature:

Multi-step reaction with 3 steps

1: aqueous ammonium chloride; zinc

2: diethyl ether / anschliessenden Behandeln mit wss. Ammoniumchlorid-Loesung

3: aq.-ethanolic ammonia; copper (II)-acetate; air

With ammonium hydroxide; air; diethyl ether; ammonium chloride; copper diacetate; zinc;

upstream raw materials:

1-Hydroxy-2,2,4,4-tetramethylpyrrolidine

2,4,4-trimethyl-1-pyrroline N-oxide

4,4-dimethyl-5-nitropentan-2-one

Downstream raw materials:

C₁₄H₂₀NO

Refernces