(2R)-2-Benzoyloxy-bernsteinsaeuredimethylester

Base Information

• Chemical Name: (2R)-2-Benzoyloxy-bernsteinsaeuredimethylester
• CAS No.: 79413-92-6
• Molecular Formula: C₁₃H₁₄O₆
• Molecular Weight: 266.251
• Mol file: 79413-92-6.mol

Synonyms:(2R)-2-Benzoyloxy-bernsteinsaeuredimethylester

Chemical Property of (2R)-2-Benzoyloxy-bernsteinsaeuredimethylester

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-2-Benzoyloxy-bernsteinsaeuredimethylester

There total 3 articles about (2R)-2-Benzoyloxy-bernsteinsaeuredimethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(2S,3S)-2-Benzoyloxy-3-brom-bernsteinsaeuredimethylester (79413-91-5) → (2R)-2-Benzoyloxy-bernsteinsaeuredimethylester (79413-92-6)

Guidance literature:

With tributylzinc hydride; azobisisobutyronitrile; In toluene; at 80 ℃; for 2h;

DOI:10.1002/hlca.19810640523

Reference yield:

dimethyl 2,3-O-benzylidene-L-tartrate (38270-72-3) → (2R)-2-Benzoyloxy-bernsteinsaeuredimethylester (79413-92-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / N-bromosuccinimide (NBS), 48 percent HBr / CCl₄ / 1 h / Heating

2: 88 percent / tributylzinnhydride, α,α'-azoisobutyronitrile / toluene / 2 h / 80 °C

With N-Bromosuccinimide; tributylzinc hydride; azobisisobutyronitrile; hydrogen bromide; In tetrachloromethane; toluene;

DOI:10.1002/hlca.19810640523

Reference yield:

→ dimethyl 2-(benzoyloxy)succinate (65582-59-4,79413-92-6)

Guidance literature:

benzoyl--dimethyl ester; /BRN= 3218347/;

upstream raw materials:

(2S,3S)-2-Benzoyloxy-3-brom-bernsteinsaeuredimethylester

dimethyl 2,3-O-benzylidene-L-tartrate

Downstream raw materials:

4-methoxy-3-methylbenzophenone

diethyl (R)-malate

Refernces