Technology Process of (Z)-1-(3,3-difluoroazetidin-1-yl)-3-(3-(3-methoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)prop-2-en-1-one
There total 6 articles about (Z)-1-(3,3-difluoroazetidin-1-yl)-3-(3-(3-methoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)prop-2-en-1-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 0 ℃;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: magnesium(II) chloride hexahydrate; sodium monohydrogen sulfide x-hydrate / N,N-dimethyl-formamide / 2 h / 20 °C
2.1: diethyl ether / 12 h / 20 °C
3.1: N,N-dimethyl-formamide / 2 h / 90 °C
4.1: triethylamine / dichloromethane / 0.5 h / 15 °C
5.1: water; lithium hydroxide / tetrahydrofuran / 20 °C
5.2: Cooling with ice
6.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0 °C / Inert atmosphere
With
sodium monohydrogen sulfide x-hydrate; magnesium(II) chloride hexahydrate; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide;
In
tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: diethyl ether / 12 h / 20 °C
2.1: N,N-dimethyl-formamide / 2 h / 90 °C
3.1: triethylamine / dichloromethane / 0.5 h / 15 °C
4.1: water; lithium hydroxide / tetrahydrofuran / 20 °C
4.2: Cooling with ice
5.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0 °C / Inert atmosphere
With
water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide;
In
tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;