2-Hydroxy-6-methylbenzoic acid

Base Information

• Chemical Name: 2-Hydroxy-6-methylbenzoic acid
• CAS No.: 567-61-3
• Molecular Formula: C8H8O3
• Molecular Weight: 152.15
• Hs Code.: 2918290000
• NSC Number: 403256
• UNII: L5352FE23Y
• DSSTox Substance ID: DTXSID20205257
• Nikkaji Number: J6.524B
• Wikipedia: 6-Methylsalicylic_acid
• Wikidata: Q6172528
• Metabolomics Workbench ID: 27912
• ChEMBL ID: CHEMBL510026
• Mol file: 567-61-3.mol

Synonyms:6-methylsalicylic acid

Chemical Property of 2-Hydroxy-6-methylbenzoic acid

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Melting Point: 141.5-142 °C
• Refractive Index: 1.6
• Boiling Point: 300.4 °C at 760 mmHg
• PKA: pK1:3.32 (25°C)
• Flash Point: 149.7 °C
• PSA: 57.53000
• Density: 1.304 g/cm³
• LogP: 1.39880
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 152.047344113
• Heavy Atom Count: 11
• Complexity: 155

Purity/Quality:

99%, ^*data from raw suppliers

2-Hydroxy-6-methylbenzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(=CC=C1)O)C(=O)O

Technology Process of 2-Hydroxy-6-methylbenzoic acid

There total 32 articles about 2-Hydroxy-6-methylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-methoxy-6-methyl-benzoic acid (6161-65-5) → 2-hydroxy-6-methylbenzoic acid (567-61-3)

Guidance literature:

2-methoxy-6-methyl-benzoic acid; With boron tribromide; In dichloromethane; at 20 ℃; for 14 - 20h;

With hydrogenchloride; In dichloromethane; water; Product distribution / selectivity;

Reference yield: 99.0%

ethyl 2-hydroxy-6-methylbenzoate (6555-40-4) → 2-hydroxy-6-methylbenzoic acid (567-61-3)

Guidance literature:

With sodium hydroxide; at 95 ℃; for 2h;

DOI:10.1002/anie.201509038

Reference yield: 99.0%

2, 2, 5-trimethyl-4H-benzo[d][1,3]dioxin-4-one (438187-08-7) → 2-hydroxy-6-methylbenzoic acid (567-61-3)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; water; Heating;

DOI:10.1021/ja0352350

upstream raw materials:

2,3,5-trimethyl-chromen-4-one

2-hydroxy-6-methylbenzaldehyde

methyl 6-methylsalicylate

2-bromo-3-methylphenol

Downstream raw materials:

3,6-dihydroxy-2-methyl-benzoic acid

3-methyl-phenol

(E)-(7S,9R,10S)-9-(tert-Butyl-diphenyl-silanyloxy)-4-hydroxy-7-(3-hydroxy-propyl)-10-methyl-7,8,9,10,11,14-hexahydro-6-oxa-benzocyclododecen-5-one

(E)-(7S,9R,10S)-7-Allyl-4-hydroxy-9-(4-methoxy-benzyloxy)-10-methyl-7,8,9,10,11,14-hexahydro-6-oxa-benzocyclododecen-5-one

Refernces

• 1、 Asahina,Kondo. "-". . . Retrieved 1922.
• 2、 Zhu, Daqian,Li, Min,Wu, Zhouming,Du, Yongliang,Luo, Bingling,Huang, Peng,Wen, Shijun. "Copper-Catalyzed One-Pot Synthesis of Dibenzofurans, Xanthenes, and Xanthones from Cyclic Diphenyl Iodoniums". supporting information. p. 4566 - 4571. Retrieved 2019/07/09.
• 3、 Mukkamala, Ramesh,Hossain, Asik,Singh Aidhen, Indrapal. "Valuable building block for the synthesis of lunularic acid, hydrangeic acid and their analogues". . p. 1085 - 1090. Retrieved 2017/01/28.