6-(2-Ethoxy-1-naphthamido)penicillin

Base Information

• Chemical Name: 6-(2-Ethoxy-1-naphthamido)penicillin
• CAS No.: 985-16-0
• Molecular Formula: C21H21N2NaO5S
• Molecular Weight: 436.46
• Mol file: 985-16-0.mol

Synonyms:Nafcillin sodium salt;Nafcillin sodium salt monohydrate;6-(2-Ethoxy-1-naphthamido)penicillin;SCHEMBL34124;FZWUJBMAAITKNH-FRFVDRIFSA-N

Chemical Property of 6-(2-Ethoxy-1-naphthamido)penicillin

Chemical Property:

• Boiling Point: 714.1oC at 760mmHg
• PKA: pKa 2.65(H2O,t = 25±0.1,c=0.006) (Uncertain)
• Flash Point: 385.7oC
• PSA: 124.07000
• Density: 1.42g/cm3
• LogP: 1.47790
• Storage Temp.: Store at 0-5°C
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 5
• Exact Mass: 437.11471226
• Heavy Atom Count: 30
• Complexity: 699

Purity/Quality:

99.9% ^*data from raw suppliers

Nafcillin sodium salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 42/43
• Safety Statements: 22-36/37-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=C(C2=CC=CC=C2C=C1)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)O.[Na]
• Isomeric SMILES: CCOC1=C(C2=CC=CC=C2C=C1)C(=O)N[C@H]3[C@@H]4N(C3=O)[C@H](C(S4)(C)C)C(=O)O.[Na]
• Uses: As a synthetic beta-lactamase-resistant penicillin, Nafcillin SodiuM Salt can be used to treat infections caused by Gram-positive bacteria, in particular, species of staphylococci that are resistant to other penicillins. Nafcillin SodiuM Salt can be used as narcotic antagonist Nafcillin Sodium Salt is an antibiotic of the penicillin class that is resistant to beta-lactamase. It can also be used as analyte for biological study and analytical study of hybrid quadrupole-orbitrap mass spectrometry analysis for high-throughput screening and quantification of multi-xenobiotics in honey.
• Indications: It is effective against Gram-positive cocci and staphylococci that produce penicillinase. It is used for the same indications as methicillin. Synonyms of this drug are nafcil, nalpen, unipen, and others. Another type of semisynthetic penicillin that should undoubtedly be considered is penicillin derivatives of heteroylcarboxylic acids (as a rule an isoxazol) in the third position of which is present a substituted or nonsubstituted phenyl radical (oxacillin, cloxacillin, dicloxacillin), which plays the role of the radical in the acyl side group. These penicillins (oxacillin, cloxacillin, dicloxacillin), which are resistant to penicillinase, are active with respect to penicillin-G-resistant staphylococci. Their antimicrobial spectrum is restricted to Gram-positive microorganisms. Penicillins that are resistant to penicillinase are the drug of choice for infections resistant to penicillin G, Staph. aureus, or coagulase-negative staphylococci. They are also effective for infections caused by nonenterococcus types of streptococci, such as streptococci groups A, B, C, and G, as well as pneumococci.
• Therapeutic Function: Antibacterial
• Clinical Use: Uses are those of group 3 penicillins . Nafcillin has been particularly recommended for the treatment of staphylococcal bacteremia caused by susceptible strains.