Methylene Blue

Base Information

• Chemical Name: Methylene Blue
• CAS No.: 61-73-4
• Deprecated CAS: 105504-42-5,121067-62-7,1341-90-8,167498-52-4,6476-03-5,97130-83-1,12262-49-6,1001913-24-1,1001914-35-7,1219638-11-5,923927-02-0,1001913-24-1,1001914-35-7,1219638-11-5,12262-49-6,1341-90-8,152071-32-4,167498-52-4,6476-03-5,923927-02-0,97130-83-1
• Molecular Formula: C16H18ClN3S
• Molecular Weight: 319.88
• Hs Code.: 32049010
• European Community (EC) Number: 200-515-2,686-172-3
• NSC Number: 759135,215213,3089,617593
• UNII: 8NAP7826UB
• DSSTox Substance ID: DTXSID0023296
• Wikipedia: Methylene_blue
• Wikidata: Q422134
• NCI Thesaurus Code: C175730
• RXCUI: 2198975
• Pharos Ligand ID: RT814RHG5L5D
• Metabolomics Workbench ID: 152273
• ChEMBL ID: CHEMBL405110
• Mol file: 61-73-4.mol

Synonyms:C.I. BasicBlue 9 (6CI,8CI);Phenothiazin-5-ium, 3,7-bis(dimethylamino)-, chloride (9CI);Basic Blue 9;C.I. Solvent Blue 8;Calcozine Blue ZF;Izit Crystal Dye;Leather Pure Blue HB;Methylene Blue 2B;Methylene Blue 2BN;Methylene Blue2BP;Methylene Blue A;Methylene Blue BB;Methylene Blue BP;Methylene Blue BPC;Methylene Blue BX;Methylene Blue FZ;Methylene Blue G;MethyleneBlue SG;Methylene Blue SP;Methylene Blue ZF;Methylene Blue ZX;Methylene bluepolychrome;NSC 617593;Sandocryl Blue BRL;Schultz 1038;Solvent Blue 8;Tetramethylthioninechloride;Urolene Blue;Virostat;Yamamoto Methylene Blue B;Yamamoto MethyleneBlue ZF;

Chemical Property of Methylene Blue

Chemical Property:

• Appearance/Colour: green fine crystalline powder
• Melting Point: 190 °C (dec.)(lit.)
• Refractive Index: n20/D1.347
• PKA: 2.6, 11.2(at 25℃)
• Flash Point: 45 °C
• PSA: 47.38000
• Density: 1.0 g/mL at 20 °C
• LogP: -0.49710
• Storage Temp.: Store at RT
• Solubility.: Soluble in water, ethanol, ethylene glycol, methyl cellosolve
• Water Solubility.: 40 g/L (20 ºC)
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 319.0909965
• Heavy Atom Count: 21
• Complexity: 483

Purity/Quality:

98%min ^*data from raw suppliers

Methylene Blue ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 10-41-22-20/21/22-36/37/38
• Safety Statements: 26-39-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Dyes -> Azine Dyes
• Canonical SMILES: CN(C)C1=CC2=C(C=C1)N=C3C=CC(=[N+](C)C)C=C3S2.[Cl-]
• Recent ClinicalTrials: The Effect of Combination Therapy of Oral MB and PRP-FG in Patients With Non-healing Diabetic Foot Ulcer
• Recent EU Clinical Trials: Photodynamic therapy of antifungal resistant dermatophytes
• Recent NIPH Clinical Trials: Utility comparison test of super -magnifying endoscope for superficial duodenal epithetlial tumors (SDETs)
• Uses: A useful inhibitor of cGMP-mediated processes and a useful stain Methylene Blue, 1% w/v aqueous solution is used as a dye in different staining procedures viz. Wright's stain and Jenner's stain. It also serves as an indicator and medicine. Further, it is used to examine RNA and DNA under the microscope or in a gel. It is widely used as a redox indicator in analytical chemistry. It is also used in the sulfide analysis.
• Clinical Use: Methylene blue is 3,7-bis(dimethylamino)-phenazathioniumchloride (Urised). The compound occurs as a dark greencrystalline powder with a metallic appearance that is solublein water (1:25) and alcohol (1:65).Methylene blue has weak antiseptic properties that makeit useful for the treatment of cystitis and urethritis. The actionof methylene blue is considered to be bacteriostatic.The compound colors the urine and stool blue green.