(3-FLUOROBENZYL)METHYLAMINE

Base Information

• Chemical Name: (3-FLUOROBENZYL)METHYLAMINE
• CAS No.: 90389-84-7
• Molecular Formula: C8H10 F N
• Molecular Weight: 139.173
• Hs Code.: 29214990
• Mol file: 90389-84-7.mol

Synonyms:(3-Fluorobenzyl)methylamine;1-(3-Fluorophenyl)-N-methylmethanamine; N-(3-Fluorobenzyl)-N-methylamine;N-(3-Fluorobenzyl)methylamine; N-Methyl-3-fluorobenzylamine

Chemical Property of (3-FLUOROBENZYL)METHYLAMINE

Chemical Property:

• Vapor Pressure: 1.6mmHg at 25°C
• Refractive Index: n20/D 1.4990(lit.)
• Boiling Point: 183-184 ºC
• PKA: 9.39±0.10(Predicted)
• Flash Point: 67 ºC
• PSA: 12.03000
• Density: 1.015
• LogP: 1.93600
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Fluoro-n-methylbenzylamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-36/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3-FLUOROBENZYL)METHYLAMINE

There total 5 articles about (3-FLUOROBENZYL)METHYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methylamine (74-89-5) + 3-Fluorobenzaldehyde (456-48-4) → 1-(3-fluorophenyl)-N-methylmethanamine (90389-84-7)

Guidance literature:

methylamine; 3-Fluorobenzaldehyde; In methanol; water; at 20 ℃; for 6h;

With sodium tetrahydroborate; In methanol; water; at 0 - 20 ℃; for 16.5h;

Reference yield: 90.5%

methylamine hydrochloride (593-51-1) + 3-Fluorobenzaldehyde (456-48-4) → 1-(3-fluorophenyl)-N-methylmethanamine (90389-84-7)

Guidance literature:

methylamine hydrochloride; With potassium carbonate; In methanol; for 1h;

3-Fluorobenzaldehyde; In methanol; at 20 ℃; for 2h;

With methanol; sodium tetrahydroborate; at 0 ℃; for 1h;

DOI:10.1016/j.bmc.2020.115811

Reference yield:

1-(3-fluorophenyl)-N-methylmethanimine → 1-(3-fluorophenyl)-N-methylmethanamine (90389-84-7)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 2h; Heating;

DOI:10.1021/jm00375a005

upstream raw materials:

methylamine

3-Fluorobenzaldehyde

m-fluorobenzyl chloride

methylamine hydrochloride

Downstream raw materials:

N-(3-fluorobenzyl)-N-methyl-N'-(5-methyl-1,3-thiazol-2-yl)urea

3-[[(3-fluorobenzyl)-methyl-amino]methyl]-5-(pyridin-4-yl)-1,3,4-oxadiazol-2(3H)-one

Refernces

• 1、 Ren, Yan,Su, Yaning,Sun, Liming,He, Sudan,Meng, Lingjun,Liao, Daohong,Liu, Xiao,Ma, Yongfen,Liu, Chunyan,Li, Sisi,Ruan, Hanying,Lei, Xiaoguang,Wang, Xiaodong,Zhang, Zhiyuan. "Discovery of a Highly Potent, Selective, and Metabolically Stable Inhibitor of Receptor-Interacting Protein 1 (RIP1) for the Treatment of Systemic Inflammatory Response Syndrome". . p. 972 - 986. Retrieved 2017/02/19.
• 2、 Zampieri, Daniele,Mamolo, Maria Grazia,Laurini, Erik,Fermeglia, Maurizio,Posocco, Paola,Pricl, Sabrina,Banfi, Elena,Scialino, Giuditta,Vio, Luciano. "Antimycobacterial activity of new 3,5-disubstituted 1,3,4-oxadiazol-2(3H)-one derivatives. Molecular modeling investigations". experimental part. p. 4693 - 4707. Retrieved 2009/10/24.