5'-ADENYLIC ACID, MONOANHYDRIDE WITH (DICHLOROPHOSPHONOMETHYL)PHOSPHONIC ACID

Base Information

• Chemical Name: 5'-ADENYLIC ACID, MONOANHYDRIDE WITH (DICHLOROPHOSPHONOMETHYL)PHOSPHONIC ACID
• CAS No.: 81336-74-5
• Molecular Formula: C₁₁H₁₆Cl₂N₅O₁₂P₃
• Molecular Weight: 574.102
• Mol file: 81336-74-5.mol

Synonyms:5'-Adenylicacid, monoanhydride with (dichloromethylene)bis[phosphonic acid] (9CI)

Chemical Property of 5'-ADENYLIC ACID, MONOANHYDRIDE WITH (DICHLOROPHOSPHONOMETHYL)PHOSPHONIC ACID

Chemical Property:

• PSA: 258.87000
• LogP: 1.55610

Purity/Quality:

97% ^*data from raw suppliers

5'-ADENYLIC ACID MONOANHYDRIDE(DICHLOROPHOSPHONOMETHYL)PHOSPHONIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5'-ADENYLIC ACID, MONOANHYDRIDE WITH (DICHLOROPHOSPHONOMETHYL)PHOSPHONIC ACID

There total 2 articles about 5'-ADENYLIC ACID, MONOANHYDRIDE WITH (DICHLOROPHOSPHONOMETHYL)PHOSPHONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

clodronate (10596-23-3) + C10H12Cl2N5O5P (34051-17-7) → adenosine 5'-(β,γ-dichloromethylene)triphosphate (81336-74-5)

Guidance literature:

clodronate; With tributyl-amine; In ethanol; water; pH=7 - 8;

C₁₀H₁₂Cl₂N₅O₅P; With tributyl-amine; In N,N-dimethyl-formamide; Inert atmosphere; Cooling;

With water; In N,N-dimethyl-formamide; at 20 ℃; for 1h; pH=7.4 - 7.6; Cooling; Inert atmosphere;

DOI:10.3389/fphar.2020.01294

Reference yield:

adenosine (58-61-7) → adenosine 5'-(β,γ-dichloromethylene)triphosphate (81336-74-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; trimethyl phosphite; trichlorophosphate / Inert atmosphere; Cooling

2.1: tributyl-amine / ethanol; water / pH 7 - 8

2.2: Inert atmosphere; Cooling

2.3: 3407 / 1 h / 20 °C / pH 7.4 - 7.6 / Cooling; Inert atmosphere

With trimethyl phosphite; tributyl-amine; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; trichlorophosphate; In ethanol; water;

DOI:10.3389/fphar.2020.01294

upstream raw materials:

adenosine

clodronate

C₁₀H₁₂Cl₂N₅O₅P

Refernces