Phenobarbital sodium

Base Information

• Chemical Name: Phenobarbital sodium
• CAS No.: 57-30-7
• Molecular Formula: C12H11N2NaO3
• Molecular Weight: 302.265
• Mol file: 57-30-7.mol

Synonyms:2,4,6(1H,3H,5H)-Pyrimidinetrione,5-ethyl-5-phenyl-, monosodium salt (9CI);Barbituric acid, 5-ethyl-5-phenyl-,sodium salt (8CI);5-Ethyl-5-phenylbarbituric acid sodium;Gardenal sodium;Linasen;Luminal sodium;PBS;Phenemalum;Phenobal;Phenobal sodium;Phenobarbital sodium;Phenobarbitone sodium;Sodium5-ethyl-5-phenylbarbiturate;Sodium ethylphenylbarbiturate;Sodium luminal;Sodium phenobarbital;Sodium phenobarbitone;Sodium phenylethylbarbiturate;Sodium phenylethylmalonylurea;Sol phenobarbitone;Solublephenobarbital;Soluble phenobarbitone;

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Chemical Property of Phenobarbital sodium

Chemical Property:

• Appearance/Colour: Odorless white crystalline powder
• Vapor Pressure: 1.32E-06mmHg at 25°C
• Melting Point: 175°C
• Boiling Point: 384.7°C at 760 mmHg
• Flash Point: 186.5°C
• PSA: 81.59000
• LogP: 0.54170
• Solubility.: H2O: 1 g/mL
• Water Solubility.: >=10 g/100 mL at 20 ºC

Purity/Quality:

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25-40-43
• Safety Statements: 22-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Phenobarbital sodium salt has been used: to anesthetize mice for inducing ischemia-reperfusion injuryas a positive control for the activation of constitutive androstane receptor (CAR)in bioluminescent yeast bioreporters (BLYAS) assay Anticonvulsant; sedative-hypnotic.

Technology Process of Phenobarbital sodium

There total 4 articles about Phenobarbital sodium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5,5-diphenylbarbituric acid (21914-07-8) → sodium phenobarbital (57-30-7)

Guidance literature:

With sodium hydroxide; In ethanol; at 20 ℃; for 2.5h; Product distribution / selectivity;

Reference yield:

phenobarbital (50-06-6) → phenobartital sodium (57-30-7)

Guidance literature:

With sodium hydroxide; In acetone;

Reference yield:

Na(1+)*Ag(1+)*2C12H11N2O3(1-)*H2O=Na{Ag(C12H11N2O3)2}*H2O + silver nitrate → phenobartital sodium (57-30-7) + Ag-phenobarbital (89263-39-8,95011-19-1)

Guidance literature:

upstream raw materials:

phenobarbital

5,5-diphenylbarbituric acid

Downstream raw materials:

5-ethyl-1-(2-methylsulfanyl-ethyl)-5-phenyl-barbituric acid

1-(2-Hydroxyaethyl)-5-phenyl-5-aethylbarbitursaeure

1-(2,3-Dihydroxy-propyl)-5-ethyl-5-phenyl-barbitursaeure

1,3-diacetyl-5-ethyl-5-phenyl-pyrimidine-2,4,6-trione

Refernces

• 1、 -. "COMPOSITION AND METHOD FOR IMPROVED BIOAVAILABILITY AND ENHANCED BRAIN DELIVERY OF 5,5-DIPHENYL BARBITURIC ACID". Page/Page column 33. . Retrieved 2008/06/13.