Sodium Fluoride

Base Information

• Chemical Name: Sodium Fluoride
• CAS No.: 7681-49-4
• Deprecated CAS: 39287-69-9,59217-75-3,67112-29-2,2018280-11-8,59217-75-3,67112-29-2
• Molecular Formula: FNa
• Molecular Weight: 41.9882
• Hs Code.: 2826.11
• European Community (EC) Number: 231-667-8
• ICSC Number: 0951
• NSC Number: 77385
• UN Number: 1690
• UNII: 8ZYQ1474W7
• DSSTox Substance ID: DTXSID2020630
• Nikkaji Number: J44.030B
• Wikipedia: Sodium fluoride,Disodium difluoride,Villiaumite
• Wikidata: Q407520
• NCI Thesaurus Code: C832
• RXCUI: 9873
• ChEMBL ID: CHEMBL1528
• Mol file: 7681-49-4.mol

Synonyms:Fluoride, Sodium;Fluorides, Sodium;Fluoristat;Fluoristats;Ossin;Ossins;Sodium Fluoride;Sodium Fluorides;Zymafluor;Zymafluors

Chemical Property of Sodium Fluoride

Chemical Property:

• Appearance/Colour: White solid
• Vapor Pressure: 1.4 mm Hg ( 0 °C)
• Melting Point: 993 °C(lit.)
• Refractive Index: 1.336
• Boiling Point: 1695 °C
• Flash Point: 1704°C
• PSA: 0.00000
• Density: 2.558 g/cm³
• LogP: -2.99600
• Storage Temp.: 2-8°C
• Sensitive.: Hygroscopic
• Solubility.: H2O: 0.5 M at 20 °C, clear, colorless
• Water Solubility.: 4 g/100 mL (25 ºC)
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 41.98817244
• Heavy Atom Count: 2
• Complexity: 2
• Transport DOT Label: Poison

Purity/Quality:

98.0% ^*data from raw suppliers

Sodium fluoride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T,Xn
• Statements: 25-32-36/38-22
• Safety Statements: 23-24/25-45-36-22

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Classes -> Fluorides, Inorganic
• Canonical SMILES: [F-].[Na+]
• Recent ClinicalTrials: Oral Hygiene and Maternity Outcomes Multicenter Study (OHMOM)
• Recent EU Clinical Trials: A Randomised controlled trial to Evaluate the effectiveness and cost benefit of prescribing high dose FLuoride toothpaste in preventing and treating dEntal Caries in high-risk older adulTs (REFLECT trial)
• Recent NIPH Clinical Trials: A multi-center randomized controlled clinical trial to examine the clinical, biochemical and antimicrobial effects of a mouth rinse on patients with mild periodontal disease.
• Inhalation Risk: Evaporation at 20 °C is negligible; a harmful concentration of airborne particles can, however, be reached quickly on spraying or when dispersed, especially if powdered.
• Effects of Short Term Exposure: The substance is irritating to the eyes, skin and respiratory tract. Ingestion could cause hypocalcaemia and hypokalaemia. This may result in central nervous system disorders and cardiac disorders.
• Effects of Long Term Exposure: The substance may have effects on the bones and teeth. This may result in fluorosis.
• Uses: 1.?Sodium fluoride is mainly used as Inlaid steel for mechanical blade and planer to enhance weld strength. Secondly, it is used as wood preservatives, fungicides in brewing industry, agricultural pesticides (should be infected with blue), medical preservatives, welding flux, fluorine agent for drinking water. Also used for producing other fluoride and casein glue, sodium fluoride toothpaste, as adhesives, also used in paper and metallurgical industries. In the production of elemental fluorine, it is used for removing trace amounts of hydrogen fluoride. In addition, it is also used in enamels and pharmaceutical industries. 2.? Sodium fluoride is used as disinfectants, preservatives, pesticides, also used in enamel, wood preservation, medicine, metallurgy, manufacturing of fluorides and so on. 3.? Used for determination of scandium in microanalysis, determination of phosphorus in photoelectric colorimetric analysis, used as reagent, the masking agents, preservatives of iron and steel. 4.? As food supplements. According to Chinese regulations for salt, the maximum usage is 0.1g/kg. 5.? It is used as wood preservatives, pharmaceutical preservative, welding flux and used in paper industry, this company's products are specific level toothpastes, can also be used as purifying agent for drinking water, and used for hides and skin processing in tanning industry, for smelting and refining of light metal, and protection layer of light metal, for adhesive corrosion, and manufacturing boiling steel. 6.? Sodium fluoride is used as the Phosphate accelerator in coating industry, makes phosphating solution stability, phosphate refinement, improves the performance of phosphate coating. Aluminum and its alloys phosphate can close negative catalytic Al3 + of great danger, and make phosphating smoothly. It is used as wood preservatives, agricultural pesticides, fungicides in brewing industry, pharmaceutical preservative, welding flux, alkaline zincate zinc additives and enamel, paper and so on. Sodium fluoride (NaF), in the concentration of one ppm, is added to municipal drinking water to help reduce tooth decay. It is also used as an insecticide, fungicide, and rodenticide, as well as in the manufacture of adhesives, disinfectants, and dental products. Sodium fluoride, formed by reaction of sodium carbonate and hydrofluoric acid, and then evaporating. Used (1) as an antiseptic and antifermentative in alcohol distilleries, (2) as a food preservative, (3) as a poison for rats and roaches, (4) as a constituent of ceramic enamels and fluxes; sodium hydrogen fluoride, sodium difluoride, sodium acid fluoride, NaHF2, white solid, soluble, formed by reaction of sodium carbonate and excess hydrofluoric acid, and then evaporating. Used (1) as an antiseptic, (2) for etching glass, (3) as a food preservative, (4) for preserving zoological specimens. As insecticide, particularly for roaches and ants; in other pesticide formulations; constituent of vitreous enamel and glass mixes; as a steel degassing agent; in electroplating; in fluxes; in heat-treating salt compositions; in the fluoridation of drinking water; for disinfecting fermentation apparatus in breweries and distilleries; preserving wood, pastes and mucilage; manufacture of coated paper; frosting glass; in removal of HF from exhaust gases to reduce air pollution. Dental caries prophylactic.
• Production method: Melt immersion method Calcine the fluorite, quartz sand and soda ash at high temperature (800~900 ℃), followed by water leaching, and then by evaporation, crystallization, drying to prepare products. CaF2 + Na2CO3 + SiO2 → 2NaF + CaSi03 + C02 ↑ Neutralizational process It is derived from neutralization of soda ash or caustic soda with hydrofluoric acid, 2HF + Na2CO3 → 2NaF + H2O + CO2 ↑ Dissolve soda in the pot liquor, and then add 30% hydrofluoric acid to neutralize to a pH value of 8-9, until CO2 gas evolution, hydrofluoric acid often contains fluosilicate impurities, and after neutralization to generate sodium fluosilicate, heating for 1h at 90~95 ℃, sodium fluosilicate decomposes: Na2SiF6 + 2Na2CO3 → 6NaF + SiO2 + 2C02 ↑ And during the process of neutralization, pH value is not less than 8, otherwise sodium fluoride is difficult to decompose by base, and neutralization solution is allowed to stand for 1h, serum is cooled and concentrated to precipitate sodium fluoride crystals and then separated by centrifugation, drying, crushing to obtain products. Sodium fluosilicate method As the byproduct of the wet process of phosphoric acid and phosphate fertilizer, fluosilicic acid may prepare 99.87% sodium fluoride by conventional methods. The reaction lasts 160~180min at 84~95 ℃ and 0.15MPa conditions, with an excess of 5% to 8% alkaline solution (pH value 8-9) to prepare sodium fluoride. Na2SiF6 + 2Na2Co3 → 6NaF + SiO2 + 2C02 ↑ After standing and clarification of neutralization solution, the supernatant was concentrated by evaporation, cooling crystallization, after separation, wash with hot water of 50~60 ℃, indirectly dry to obtain products.
• Description: Sodium fluoride, NaF, is a binary salt that is a clear, lustrous crystal or white powder. The insecticide grade is frequently dyed blue. It is soluble in water and has a specific gravity of 2.558, which is heavier than water. Sodium fluoride is highly toxic by ingestion and inhalation, and is also strongly irritating to tissue. The TLV is 2.5 mg/m3 of air. The four-digit UN identification number is 1690. The primary uses are fluoridation of municipal water at 1 ppm, as an insecticide, rodenticide, and fungicide, and in toothpastes and disinfectants.
• Physical properties: Colorless cubic or tetragonal crystals; density 2.78 g/cm3; melts at 993°C; vaporizes at 1,695°C; moderately soluble in water 4.22 g/100mL at 18°C; soluble in hydrofluoric acid; insoluble in ethanol.
• Clinical Use: Sodium fluoride (NaF) promotes the proliferation and activity of osteoblasts and is classified as a nonhormonal bone-forming agent. Because treatment with NaF induces bone formation, it is essential that this therapy be coupled with oral calcium supplementation (1,000 mg/day). Additionally, NaF exhibits moderate antiresorptive activity, because it inhibits osteoclastic activity when it is absorbed into the bone matrix. In the treatment of osteoporosis, the therapeutic window for this agent is fairly narrow: Doses less than 45 mg/day are subtherapeutic, and doses in excess of 75 mg/day impair bone mineralization. In addition, the bone that is formed in the presence of NaF is neither as well mineralized nor as strong as normal bone tissue. In fact, some

Technology Process of Sodium Fluoride

There total 64 articles about Sodium Fluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

difluoro-nitro-methane (1493-05-6) + sodium ethanolate (141-52-6) → sodium fluoride (7681-49-4) + sodium nitrite (7632-00-0) + Diethyl carbonate (105-58-8,76619-83-5)

Guidance literature:

In ethanol; dichloromethane; alkoxide soln. (EtOH) addn. to F2C(NO2)2 soln. (CH2Cl2) (molar ratio F2C(NO2)2:nucleophile=1:4), reacting (-10°C for 10-15 min), stirring (0°C for 1 h, then 20°C for 1 h); salts. ppt. sepn. (CH2Cl2 addn.); chem. and GLC anal.;

Reference yield: 78.0%

sodium cyanide (773837-37-9) + zinc(II) nitrate hexahydrate → zinc(II) cyanide (557-21-1) + sodium fluoride (7681-49-4)

Guidance literature:

In water; compds. dissolved in degassed H2O at 80°C, allowed to stand for 1d at 4°C; NaF filtered off, washed with ice-cold EtOH, aq. EtOH mixt. evapd.;

Reference yield: 45.0%

fluorine (7782-41-4) + sodium hydroxide (1310-73-2) → difluoroether (7783-41-7) + sodium fluoride (7681-49-4)

Guidance literature:

In sodium hydroxide; byproducts: H2O; F2 is passed through tube of Pt into a 2% aq. soln. of NaOH;; washing with water; condensation with liq. air; fractional distn.;;

upstream raw materials:

sodium carbonate

potassium carbonate

hydrogen fluoride

fluorotrinitromethane

Downstream raw materials:

lithium fluoride

magnesium fluoride

potassium fluoride

{Ph-C(NSiMe₃)2}2ZrCl₂

Refernces

• 1、 Zherin,Rudnikov,Ostvald,Sobolev,Amelina. "Sorption and desorption of BrF3 on NaF: Studies on thermodynamics and kinetics". . p. 25 - 33. Retrieved 2019.
• 2、 Hood, G. C.,Woyski, M. M.. "". . p. 2738 - 2741. Retrieved 1951.
• 3、 Fedorova, Anna A.,Fedulin, Andrey I.,Morozov, Igor V.. "New method of beta-NaYF4: Yb3+, Er3+ synthesis by using beta-cyclodextrin". . p. 173 - 177. Retrieved 2015/08/06.