(2-iodo-3-methylphenyl)(phenyl)methanone

Base Information

• Chemical Name: (2-iodo-3-methylphenyl)(phenyl)methanone
• CAS No.: 52164-35-9
• Molecular Formula: C₁₄H₁₁IO
• Molecular Weight: 322.145
• Mol file: 52164-35-9.mol

Synonyms:(2-iodo-3-methylphenyl)(phenyl)methanone

Chemical Property of (2-iodo-3-methylphenyl)(phenyl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-iodo-3-methylphenyl)(phenyl)methanone

There total 4 articles about (2-iodo-3-methylphenyl)(phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-amino-3-methylphenyl)(phenyl)methanone (5054-32-0) → (2-iodo-3-methylphenyl)(phenyl)methanone (52164-35-9)

Guidance literature:

With toluene-4-sulfonic acid; potassium iodide; sodium nitrite; In water; acetonitrile; at 20 ℃; for 2h;

DOI:10.1021/acs.joc.9b01418

Reference yield:

3-methylantranilic acid (4389-45-1) → (2-iodo-3-methylphenyl)(phenyl)methanone (52164-35-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

1.2: Inert atmosphere; Reflux

2.1: n-butyllithium / tetrahydrofuran / -78 °C / Inert atmosphere

3.1: toluene-4-sulfonic acid; sodium nitrite; potassium iodide / acetonitrile; water / 2 h / 20 °C

With n-butyllithium; toluene-4-sulfonic acid; 1,1'-carbonyldiimidazole; potassium iodide; sodium nitrite; In tetrahydrofuran; water; acetonitrile;

DOI:10.1021/acs.joc.9b01418

Reference yield:

bromobenzene (108-86-1,52753-63-6) → (2-iodo-3-methylphenyl)(phenyl)methanone (52164-35-9)

Guidance literature:

Multi-step reaction with 2 steps

1: n-butyllithium / tetrahydrofuran / -78 °C / Inert atmosphere

2: toluene-4-sulfonic acid; sodium nitrite; potassium iodide / acetonitrile; water / 2 h / 20 °C

With n-butyllithium; toluene-4-sulfonic acid; potassium iodide; sodium nitrite; In tetrahydrofuran; water; acetonitrile;

DOI:10.1021/acs.joc.9b01418

upstream raw materials:

2-amino-3-methylbenzonitrile

(2-amino-3-methylphenyl)(phenyl)methanone

bromobenzene

3-methylantranilic acid

Refernces

• 1、 Li, Quanzhe,Liu, Jiaxin,Shi, Min,Wei, Yin. "Visible Light Induced Cyclization to Spirobi[indene] Skeletons from Functionalized Alkylidienecyclopropanes". supporting information. . Retrieved 2020/03/26.
• 2、 Fan, Xing,Shi, Min,Wei, Yin. "Palladium-Catalyzed Cascade Reductive and Carbonylative Cyclization of Ortho-Iodo-Tethered Methylenecyclopropanes (MCPs) Using N-Formylsaccharin as CO Source". supporting information. p. 5677 - 5683. Retrieved 2019/11/16.