Doxapram hydrochloride monohydrate

Base Information

• Chemical Name: Doxapram hydrochloride monohydrate
• CAS No.: 7081-53-0
• Molecular Formula: C24H33ClN2O3
• Molecular Weight: 432.9834
• Hs Code.: 2934990002
• European Community (EC) Number: 615-173-3
• UNII: P5RU6UOQ5Y
• DSSTox Substance ID: DTXSID60991081
• Wikidata: Q27114354
• NCI Thesaurus Code: C47500
• RXCUI: 82011
• ChEMBL ID: CHEMBL3989519
• Mol file: 7081-53-0.mol

Synonyms:7081-53-0;Doxapram hydrochloride monohydrate;Doxapram HCL;Doxapram hydrochloride hydrate;DoxapraM interMediate;Doxapram (hydrochloride hydrate);15083-72-4;Doxapram HCl H2O;AHR 619;UNII-P5RU6UOQ5Y;P5RU6UOQ5Y;AHR-619;1-ethyl-4-(2-morpholin-4-ylethyl)-3,3-diphenylpyrrolidin-2-one;hydrate;hydrochloride;1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one hydrochloride hydrate;2-Pyrrolidinone, 1-ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-,monohydrochloride, monohydrate;NSC-170958;NSC-760347;Doxapram hydrochloride [USAN:USP:JAN];Dopram (TN);2-Pyrrolidinone, 1-ethyl-4-(2-(4-morpholinyl)ethyl)-3,3-diphenyl-, monohydrochloride, monohydrate;DOXAPRAMHYDROCHLORIDE;1-Ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone monohydrochloride monohydrate;1-Ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one hydrochloride hydrate(1:x:x);Doxapram hydrochloride [USAN:JAN];1-Ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone hydrochloride hydrate;2-Pyrrolidinone, 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-, monohydrochloride, monohydrate;C24H30N2O2.ClH.H2O;2-Pyrrolidinone, 1-ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-, monohydrochloride, monohydrate;MFCD09954698;Doxapram HCl hydrate;2-Pyrrolidinone, 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-, monohydrochloride;(+-)-1-Ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone monohydrochloride monohydrate;2-Pyrrolidinone, 1-ethyl-4-(2-(4-morpholinyl)ethyl)-3,3-diphenyl-, monohydrochloride, monohydrate, (+-)-;Dopram hydrochloride hydrate;SCHEMBL40643;Respiram hydrochloride hydrate;Stimulex hydrochloride hydrate;Doxapram hydrochloride (USP);DOXAPRAM HCL MONOHYDRATE;CHEMBL3989519;HY-B0551A;DTXSID60991081;AMY17940;BCP04771;DOXAPRAM HYDROCHLORIDE [USAN];s4037;DOXAPRAM HYDROCHLORIDE [VANDF];AKOS015950783;DOXAPRAM HYDROCHLORIDE [MART.];BCP9000626;CCG-269048;DOXAPRAM HYDROCHLORIDE [USP-RS];DOXAPRAM HYDROCHLORIDE [WHO-DD];Doxapram hydrochloride hydrate (JP17);NSC 760347;AC-24281;BS-44778;C24-H30-N2-O2.Cl-H.H2-O;BCP0726000004;DOXAPRAM HYDROCHLORIDE [GREEN BOOK];DOXAPRAM HYDROCHLORIDE [ORANGE BOOK];DOXAPRAM HYDROCHLORIDE HYDRATE [JAN];DOXAPRAM HYDROCHLORIDE [EP MONOGRAPH];FT-0630362;SW197706-2;DOXAPRAM HYDROCHLORIDE [USP MONOGRAPH];C76261;D01872;DOXAPRAM HYDROCHLORIDE MONOHYDRATE [MI];EN300-268134;A837002;Q27114354;Z2569809969;1-ethyl-4-(2-morpholin-4-ylethyl)-3,3-diphenyl-pyrrolidin-2-one hydrate hydrochloride;1-ETHYL-4-(2-MORPHOLINOETHYL)-3,3-DIPHENYL-2-PYRROLIDINONE HYDROCHLORIDE;1-Ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one xhydrochloride yhydrate;1-Ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-onehydrochloridehydrate(1:x:x);1-ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-2-pyrrolidinone hydrate hydrochloride;1-ethyl-4-[2-(morpholin-4-yl)ethyl]-3,3-diphenylpyrrolidin-2-one hydrate hydrochloride;2-PYRROLIDINONE, 1-ETHYL-4-(2-MORPHOLINOETHYL)-3,3-DIPHENYL-, HYDROCHLORIDE;Doxapram Hydrochloride Monohydrate 1.0 mg/ml in Methanol (as anhydrous free base);(+/-)-1-ETHYL-4-(2-MORPHOLINOETHYL)-3,3-DIPHENYL-2-PYRROLIDINONE MONOHYDROCHLORIDE MONOHYDRATE;1-Ethyl-4-[2-(morpholin-4-yl)ethyl]-3,3-diphenylpyrrolidin-2-one--hydrogen chloride--water (1/1/1);2-PYRROLIDINONE, 1-ETHYL-4-(2-(4-MORPHOLINYL)ETHYL)-3,3-DIPHENYL-, HYDROCHLORIDE (1:1);2-PYRROLIDINONE, 1-ETHYL-4-(2-(4-MORPHOLINYL)ETHYL)-3,3-DIPHENYL-, MONOHYDROCHLORIDE, MONOHYDRATE, (+/-)-

Chemical Property of Doxapram hydrochloride monohydrate

Chemical Property:

• Melting Point: 217-219°
• Boiling Point: 536.4 °C at 760 mmHg
• Flash Point: 278.2 °C
• PSA: 42.01000
• LogP: 3.78680
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Soluble in water, in alcohol and in methylene chloride.
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 432.2179706
• Heavy Atom Count: 30
• Complexity: 487

Purity/Quality:

99% ^*data from raw suppliers

DoxapramHydrochlorideHydrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCN1CC(C(C1=O)(C2=CC=CC=C2)C3=CC=CC=C3)CCN4CCOCC4.O.Cl
• Recent EU Clinical Trials: Doxapram versus placebo in preterm newborns:
• Description: Doxapram is a central respiratory stimulant. It increases respiration and phrenic nerve activity in anesthetized cats at a dose of 1.0 mg/kg. Doxapram acts through carotid chemoreceptors, lacking activity in anesthetized cats following carotid denervation. Formulations containing doxapram have been used to increase respiration in patients with chronic pulmonary disease, respiratory depression induced by drug overdose, and to stimulate deep breathing post-anesthesia.
• Uses: antibacterial
• Clinical Use: Postoperative respiratory depressionAcute respiratory failure
• Drug interactions: Potentially hazardous interactions with other drugsAnaesthetics: increased risk of arrhythmias with volatile liquid general anaesthetics - avoid for at least 10 minutes after volatile liquid general anaesthetics.