Periciazine

Base Information

• Chemical Name: Periciazine
• CAS No.: 2622-26-6
• Molecular Formula: C21H23 N3 O S
• Molecular Weight: 365.499
• Hs Code.: 2934300000
• European Community (EC) Number: 220-071-3
• NSC Number: 758641
• UNII: 3405M6FD73
• DSSTox Substance ID: DTXSID5045910
• Nikkaji Number: J3.392H
• Wikipedia: Periciazine
• Wikidata: Q2622907
• NCI Thesaurus Code: C81580
• Pharos Ligand ID: 95SRLFPJQUAR
• Metabolomics Workbench ID: 43594
• ChEMBL ID: CHEMBL251940
• Mol file: 2622-26-6.mol

Synonyms:Aolept;Neuleptil;Neuleptyl;periciazine;pericyazine;propericiazine

Chemical Property of Periciazine

Chemical Property:

• Vapor Pressure: 6.29E-15mmHg at 25°C
• Melting Point: 116-117°
• Refractive Index: 1.6740 (estimate)
• Boiling Point: 593.4°Cat760mmHg
• PKA: 14.87±0.20(Predicted)
• Flash Point: 312.7°C
• PSA: 75.80000
• Density: 1.32g/cm³
• LogP: 4.01068
• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• Water Solubility.: 38.01mg/L(37 oC)
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 365.15618354
• Heavy Atom Count: 26
• Complexity: 513

Purity/Quality:

98%Min ^*data from raw suppliers

Pericyazine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-36/37/38-20/21/22
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCC1O)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C#N
• Recent EU Clinical Trials: Randomized multicentric open-label phase III clinical trial to evaluate the efficacy of continual treatment versus discontinuation based in the presence of prodromes in a first episode of non-affective psychosis.
• Uses: Psychotherapeutic phenothiazine. Antipsychotic. Spectrophotometric reagent for palladium and ruthenium.
• Therapeutic Function: Neuroleptic

Technology Process of Periciazine

There total 2 articles about Periciazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

4-HYDROXYPIPERIDINE (5382-16-1) + 10H-phenothiazine-2-carbonitrile (38642-74-9) + 1.3-chlorobromopropane (109-70-6) → periciazine (2622-26-6)

Guidance literature:

10H-phenothiazine-2-carbonitrile; 1.3-chlorobromopropane; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 7h;

4-HYDROXYPIPERIDINE; With triethylamine; In N,N-dimethyl-formamide; at 0 - 60 ℃; for 42h;

DOI:10.1021/acs.orglett.8b02528

Reference yield:

→ periciazine (2622-26-6)

Guidance literature:

3-Cyan-10-<3-toluol-sulfonyloxy-propyl>-phenothiazin, 4-Hydroxy-piperidin in Toluol;

upstream raw materials:

4-HYDROXYPIPERIDINE

10H-phenothiazine-2-carbonitrile

1.3-chlorobromopropane

Refernces