Piperidine hydrochloride

Base Information

• Chemical Name: Piperidine hydrochloride
• CAS No.: 6091-44-7
• Molecular Formula: C5H11N^.HCl
• Molecular Weight: 121.61
• Hs Code.: 29333200
• European Community (EC) Number: 228-033-8
• NSC Number: 27162
• UNII: 5MY66P6N3M
• DSSTox Substance ID: DTXSID20884223
• Wikidata: Q27262579
• Mol file: 6091-44-7.mol

Synonyms:Piperidine hydrochloride;6091-44-7;Piperidine, hydrochloride;piperidine;hydrochloride;Piperidinium chloride;Piperidine, hydrochloride (1:1);Hexahydropyridine hydrochloride;NSC-27162;UNII-5MY66P6N3M;5MY66P6N3M;Piperidine HCl;Pperdne hydrochlorde;C5H11N.ClH;WLN: T6MTJ &GH;SCHEMBL163097;Piperidine hydrochloride, 99%;DTXSID20884223;VEIWYFRREFUNRC-UHFFFAOYSA-N;AMY40816;BCP15342;NSC27162;STR09186;MFCD00012770;PIPERIDINE HYDROCHLORIDE [MI];AKOS002390505;FT-0635969;P0454;E79358;J-523970;Q27262579

Chemical Property of Piperidine hydrochloride

Chemical Property:

• Appearance/Colour: white fine crystalline powder
• Vapor Pressure: 63.6 mm Hg ( 37.8 °C)
• Melting Point: 245-249 °C
• Boiling Point: 106.4 °C at 760 mmHg
• Flash Point: 4.4 °C
• PSA: 16.61000
• Density: 1,12 g/cm3
• LogP: -1.69310
• Storage Temp.: Store below +30°C.
• Sensitive.: Hygroscopic
• Solubility.: >1500g/l
• Water Solubility.: soluble
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 121.0658271
• Heavy Atom Count: 7
• Complexity: 30.9

Purity/Quality:

99.9% ^*data from raw suppliers

Piperidine hydrochloride 99% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25-37-36/37/38-23/24/25
• Safety Statements: 36/37/39-45-28A-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCNCC1.Cl
• Uses: Piperidine hydrochloride is used an intermediate in the manufacture of active pharmaceutical ingredients like anti Parkinsonan agent Biperiden; anti depressant agent Clocapramine hydrochloride and muscle relaxant tolperisone. Reagent for synthesis of:Quinoline selenium compoundsPeripheral seratonin 5-HT3 receptor ligandsReactant for synthesis of phthalazinone derivatives as topically active phosphodiesterase 4 inhibitorsReactant for:Mannich reactionsAsymmetric hydrogenation of quinolinesChemoselective reductive amination of carbonyl compounds

Technology Process of Piperidine hydrochloride

There total 120 articles about Piperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

pyridine (110-86-1) → piperidine hydrochloride (6091-44-7)

Guidance literature:

pyridine; With palladium 10% on activated carbon; hydrogen; acetic acid; at 24 - 28 ℃; for 15h;

With hydrogenchloride; In methanol; water; Catalytic behavior;

DOI:10.1002/ejoc.202000695

Reference yield: 100.0%

piperidine (110-89-4) → piperidine hydrochloride (6091-44-7)

Guidance literature:

With hydroxylamine hydrochloride; In ethanol; for 2h; Reflux;

DOI:10.1080/00397911.2015.1096943

Reference yield: 100.0%

2-chloropyridine-N-oxide (2402-95-1) → piperidine hydrochloride (6091-44-7)

Guidance literature:

2-chloropyridine-N-oxide; With ammonium formate; 10percent palladium on carbon; In methanol; at 20 ℃; for 16h;

With hydrogenchloride; In methanol; Further stages.;

DOI:10.1021/jo015649g

upstream raw materials:

methanol

5-chloropentylamine

3-phenyl-4-piperidino-butan-2-one; hydrochloride

nitrobenzene

Downstream raw materials:

1-(2,4-dinitrophenyl)piperidine

1-(4-chloro-phenyl)-2-methyl-3-piperidino-propan-1-one

1-(N-Piperidino)-3-(2-nitro-phenyl)-3-oxo-propan-hydrochlorid

2,4-dihydroxy-5-piperidinomethyl-benzophenone; hydrochloride

Refernces

• 1、 Koci?cka, Paulina,Kochel, Andrzej,Szymańska-Buzar, Teresa. "Photochemical synthesis, structure and spectroscopic properties of [W(CO)4(C5H10N)2CH2]". . p. 105 - 107. Retrieved 2014.
• 2、 -. "PRODUCTION METHOD OF CYCLIC COMPOUND". Paragraph 0057; 0059; 0061; 0063. . Retrieved 2021/05/05.
• 3、 De Borggraeve, Wim M.,Gilles, Philippe,Van Mileghem, Seger,Verschueren, Rik H.. "Solvent-freeN-Boc deprotection byex situgeneration of hydrogen chloride gas". supporting information. p. 5782 - 5787. Retrieved 2021/07/12.