Technology Process of N-(2,6-diisopropylphenyl)-6-((6-((N,N-dimethylamino)methyl)benzo[d]oxazol-2-yl)thio)hexanamide
There total 10 articles about N-(2,6-diisopropylphenyl)-6-((6-((N,N-dimethylamino)methyl)benzo[d]oxazol-2-yl)thio)hexanamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N-(2,6-diisopropylphenyl)-6-((6-(hydroxymethyl)benzo[d]oxazol-2-yl)thio)hexanamide;
With
dmap; methanesulfonyl chloride; triethylamine;
In
tetrahydrofuran;
at 0 ℃;
for 0.5h;
dimethyl amine;
In
tetrahydrofuran; water;
for 1h;
Reflux;
DOI:10.1016/j.bmc.2018.06.024
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium hydroxide / tetrahydrofuran; water; tert-butyl alcohol / 12 h / 20 °C
2.1: methyl chloroformate; triethylamine / tetrahydrofuran / 0.5 h / 0 °C
2.2: 0.5 h / 20 °C
3.1: dmap; triethylamine; methanesulfonyl chloride / tetrahydrofuran / 0.5 h / 0 °C
3.2: 1 h / Reflux
With
dmap; methanesulfonyl chloride; triethylamine; methyl chloroformate; lithium hydroxide;
In
tetrahydrofuran; water; tert-butyl alcohol;
DOI:10.1016/j.bmc.2018.06.024
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate; 18-crown-6 ether / N,N-dimethyl-formamide / 2 h / 80 °C
2.1: lithium hydroxide / tetrahydrofuran; water; tert-butyl alcohol / 12 h / 20 °C
3.1: methyl chloroformate; triethylamine / tetrahydrofuran / 0.5 h / 0 °C
3.2: 0.5 h / 20 °C
4.1: dmap; triethylamine; methanesulfonyl chloride / tetrahydrofuran / 0.5 h / 0 °C
4.2: 1 h / Reflux
With
dmap; 18-crown-6 ether; potassium carbonate; methanesulfonyl chloride; triethylamine; methyl chloroformate; lithium hydroxide;
In
tetrahydrofuran; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.bmc.2018.06.024