cefotaxime sodium salt

Base Information

• Chemical Name: cefotaxime sodium salt
• CAS No.: 60846-23-3
• Molecular Formula: C₁₆H₁₆N₅O₇S₂*Na
• Molecular Weight: 477.454
• Mol file: 60846-23-3.mol

Synonyms:cefotaxime sodium salt

Chemical Property of cefotaxime sodium salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of cefotaxime sodium salt

There total 3 articles about cefotaxime sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(6R)-3-acetoxymethyl-7t-amino-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid; sodium salt (40994-22-7) + (2-Amino-thiazol-4-yl)-[(Z)-methoxyimino]-acetic acid 4,6-dimethoxy-[1,3,5]triazin-2-yl ester (207725-19-7) → cefotaxime sodium salt (60846-23-3)

Guidance literature:

With N,O-bis-dimethylsilyl acetamide; at 0 ℃; for 1.5h;

DOI:10.1080/00397919808006831

Reference yield:

cefotaxime (63527-52-6,63527-53-7,60846-21-1,152186-43-1) → cefotaxime sodium salt (60846-23-3)

Guidance literature:

cefotaxime; With sodium hydrogensulfite; In water; for 0.5h;

With sodium isooctanoate; sodium acetate; pyrographite; In water; at 0 - 5 ℃; for 0.5h; pH=6; pH-value;

Reference yield:

(Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate (80756-85-0) + (6R,7R)-Trimethylsilyl 7-(Trimethylsilyl)amino-3-acetoxy methylceph-3-em-4-carboxylate (31461-04-8) → cefotaxime sodium salt (60846-23-3)

Guidance literature:

With sodium 2-ethylhexanoic acid; Yield given. Multistep reaction; 1) CH₂Cl₂, 2) CH₂Cl₂, MeOH;

upstream raw materials:

(6R)-3-acetoxymethyl-7t-amino-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid; sodium salt

(2-Amino-thiazol-4-yl)-[(Z)-methoxyimino]-acetic acid 4,6-dimethoxy-[1,3,5]triazin-2-yl ester

(Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate

(6R,7R)-Trimethylsilyl 7-(Trimethylsilyl)amino-3-acetoxy methylceph-3-em-4-carboxylate

Downstream raw materials:

1-(isopropoxycarbonyloxy)ethyl 7β-<2-(2-aminothiazol-4-yl)-(Z)-methoxyiminoacetamido>-3-acetoxymethyl-3-cephem-4-carboxylate

desacetylcefotaxime

Refernces

• 1、 -. "Cefotaxime sodium pharmaceutical preparation in the transabdominal or vaginal hysterectomy, gastrointestinal tract and genital tract such as the prevention of infection before the application (by machine translation)". Paragraph 0138; 0141-0143; 0146-0148; 0151-0152; 0175-0176. . Retrieved 2019/11/13.