Technology Process of [(S)-1-((R)-3,3-dimethyl-5-{4-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-1H-imidazol-2-yl}-[1,3]azasilolidine-1-carbonyl)-2-methyl-propyl]-carbamic acid methylester
There total 6 articles about [(S)-1-((R)-3,3-dimethyl-5-{4-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-1H-imidazol-2-yl}-[1,3]azasilolidine-1-carbonyl)-2-methyl-propyl]-carbamic acid methylester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate;
In
1,4-dioxane;
at 100 ℃;
Overall yield = 40 %; Overall yield = 130 mg;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: potassium carbonate / dichloromethane / 2 h / 20 °C / Inert atmosphere
2: ammonium acetate / toluene / 110 - 130 °C / Inert atmosphere
3: hydrogenchloride / methanol / 2 h / 20 °C / Inert atmosphere
4: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 20 °C / Inert atmosphere
5: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 100 °C / Inert atmosphere
With
hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; ammonium acetate; potassium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU;
In
1,4-dioxane; methanol; dichloromethane; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium carbonate; sodium hydroxide / water / 0 - 20 °C / Inert atmosphere
2: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 20 °C / Inert atmosphere
3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 100 °C / Inert atmosphere
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide;
In
1,4-dioxane; dichloromethane; water;