methyl 5-<2-<<3-(1,3-benzodioxol-5-yl)-1-methylpropyl>amino>-1-hydroxyethyl>-2-hydroxybenzoate

Base Information

• Chemical Name: methyl 5-<2-<<3-(1,3-benzodioxol-5-yl)-1-methylpropyl>amino>-1-hydroxyethyl>-2-hydroxybenzoate
• CAS No.: 56290-93-8
• Molecular Formula: C₂₁H₂₅NO₆
• Molecular Weight: 387.433
• Mol file: 56290-93-8.mol

Synonyms:methyl 5-<2-<<3-(1,3-benzodioxol-5-yl)-1-methylpropyl>amino>-1-hydroxyethyl>-2-hydroxybenzoate

Chemical Property of methyl 5-<2-<<3-(1,3-benzodioxol-5-yl)-1-methylpropyl>amino>-1-hydroxyethyl>-2-hydroxybenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 5-<2-<<3-(1,3-benzodioxol-5-yl)-1-methylpropyl>amino>-1-hydroxyethyl>-2-hydroxybenzoate

There total 1 articles about methyl 5-<2-<<3-(1,3-benzodioxol-5-yl)-1-methylpropyl>amino>-1-hydroxyethyl>-2-hydroxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cassione (55418-52-5) + methyl-5-(N,N-dibenzylglycyl) salicylate (36270-04-9) → methyl 5-<2-<<3-(1,3-benzodioxol-5-yl)-1-methylpropyl>amino>-1-hydroxyethyl>-2-hydroxybenzoate (56290-93-8)

Guidance literature:

With hydrogen; acetic acid; platinum on activated charcoal; palladium oxide on charcoal; In methanol; under 760 Torr; Ambient temperature;

DOI:10.1021/jm00348a013

Reference yield: 82.0%

methyl 5-<2-<<3-(1,3-benzodioxol-5-yl)-1-methylpropyl>amino>-1-hydroxyethyl>-2-hydroxybenzoate (56290-93-8) → medroxalol (56290-94-9,90760-47-7,90760-48-8)

Guidance literature:

With ammonia; sodium methylate; In methanol; at 25 ℃; for 72h;

DOI:10.1021/jm00135a017

Reference yield:

n-Dodecylamine (124-22-1) + methyl 5-<2-<<3-(1,3-benzodioxol-5-yl)-1-methylpropyl>amino>-1-hydroxyethyl>-2-hydroxybenzoate (56290-93-8) → 5-[2-(3-Benzo[1,3]dioxol-5-yl-1-methyl-propylamino)-1-hydroxy-ethyl]-N-dodecyl-2-hydroxy-benzamide

Guidance literature:

With sodium methylate; In methanol; at 25 ℃; for 22h;

DOI:10.1021/jm00135a017

upstream raw materials:

cassione

methyl-5-(N,N-dibenzylglycyl) salicylate

Downstream raw materials:

medroxalol

Refernces