Iodine

Base Information

• Chemical Name: Iodine
• CAS No.: 7553-56-2
• Deprecated CAS: 24503-90-0,8012-81-5,8012-85-9,8031-47-8,8012-81-5,8012-85-9,8031-47-8
• Molecular Formula: I2
• Molecular Weight: 253.809
• Hs Code.: 2801200000
• European Community (EC) Number: 231-442-4
• ICSC Number: 0167
• NSC Number: 42355
• UN Number: 3495,3085
• UNII: 9679TC07X4
• DSSTox Substance ID: DTXSID7034672
• Wikipedia: Diiodine
• Wikidata: Q2064483
• NCI Thesaurus Code: C594
• RXCUI: 5933
• ChEMBL ID: CHEMBL1201225
• Mol file: 7553-56-2.mol

Synonyms:Iodine;Iodine 127;Iodine-127

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Iodine

Chemical Property:

• Appearance/Colour: Grey to purple solid
• Vapor Pressure: 0.49mmHg at 25°C
• Melting Point: 113 °C(lit.)
• Refractive Index: 1.788
• Boiling Point: 184.35 °C at 760 mmHg
• PSA: 0.00000
• Density: 3.835 g/cm³
• LogP: 1.77140
• Solubility.: Very slightly soluble in water; freely soluble in carbon disulfide, in chloroform, in carbon tetrachloride, and in ether; soluble in alcohol and in solutions of iodides; sparingly soluble in glycerin.
• Water Solubility.: 0.3 g/L (20℃)
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 0
• Exact Mass: 253.80895
• Heavy Atom Count: 2
• Complexity: 0
• Transport DOT Label: Corrosive Poison

Purity/Quality:

Safty Information:

• Pictogram(s): Xn, N
• Hazard Codes: Xn:Harmful;;
• Statements: R20/21:; R50:
• Safety Statements: S23:; S25:; S61:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Classes -> Elements, Nonmetallic
• Canonical SMILES: II
• Recent ClinicalTrials: Iodine Status in Swedish Lactating Women - Effect of Iodine Supplementation in the Thyroid Function of Mother and Infant
• Recent EU Clinical Trials: An open, multicenter, single dose, parallel study, evaluating the
• Recent NIPH Clinical Trials: The effect of oral disinfectant containing iodine on thyroid function. Preliminary Study: Iodine intake from mouthwash and antiseptic solution.
• Inhalation Risk: A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20 °C.
• Effects of Short Term Exposure: Lachrymation. The substance is severely irritating to the eyes and respiratory tract. The substance is irritating to the skin. Inhalation of the vapour may cause asthma-like reactions (RADS). Inhalation of the vapour may cause lung oedema. The effects may be delayed. Medical observation is indicated.
• Effects of Long Term Exposure: Repeated or prolonged contact may cause skin sensitization in rare cases. Repeated or prolonged inhalation may cause asthma-like syndrome (RADS). The substance may have effects on the thyroid.
• Sources: Iodine is naturally present in soil and seawater and can be obtained from dietary sources such as iodized table salt, seafood, and supplements.^[1]
• Chemical Composition and Structure: Iodine primarily exists as iodide (I-) or iodate (IO3-) in nature. In supplements and iodized salt, it is commonly in the form of potassium iodide (KI) or potassium iodate (KIO3).^[1]
• Medical Uses: Iodine supplementation was demonstrated in the early 20th century to prevent endemic goiter, leading to the introduction of salt iodization programs. Since then, iodine deficiency disorders have significantly declined globally, representing a major public health achievement.; Iodine is classified as a trace element and is essential for the production of thyroid hormones thyroxine (T4) and triiodothyronine (T3).^[2] Iodine is essential for thyroid hormone production and is used in the prevention and treatment of iodine deficiency disorders (IDD), including endemic goiter, cretinism, and intellectual impairment.^[1]
• Chemical Applications: Iodine is used in various industrial applications, including nuclear power, where it is employed to capture and sequester radioactive iodine residues.^[3] It also possesses antioxidant, bactericidal, antiviral, and antifungal properties and is being investigated for potential antineoplastic effects in cancer therapy.^[4]
• Mechanism of Action: Iodine regulates overall metabolism and plays a critical role in fetal and child neurodevelopment, organ, and tissue function. It is essential for the production of thyroid hormones, which regulate various physiological processes.
• References: [1] Iodine and Iodine Deficiency: A Comprehensive Review of a Re-Emerging Issue; [2] The Role of Iodine for Thyroid Function in Lactating Women and Infants; DOI 10.1210/endrev/bnab029; [3] Adsorption of iodine in metal–organic framework materials; DOI 10.1039/D0CS01192D; [4] Iodine: Its Role in Thyroid Hormone Biosynthesis and Beyond; DOI 10.3390/nu13124469

Technology Process of Iodine

There total 1550 articles about Iodine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

hydrogen iodide (10034-85-2) → hydrogen (1333-74-0) + iodine (7553-56-2,12190-71-5,8031-47-8)

Guidance literature:

Irradiation (UV/VIS); in glass vessel or uviol vessel, wavelenght higher than 2540?;; Kinetics;

Reference yield:

ethyl iodide (75-03-6) → hydrogen iodide (10034-85-2) + iodine (7553-56-2,12190-71-5,8031-47-8)

Guidance literature:

at -190 ℃; 253 nm.Photolysis;

DOI:10.1021/j150559a004

Reference yield:

ethyl iodide (75-03-6) → ethane (74-84-0) + ethene (74-85-1) + hydrogen iodide (10034-85-2) + iodine (7553-56-2,12190-71-5,8031-47-8)

Guidance literature:

mit UV-Licht; Produkt₅: Wasserstoff_.Irradiation;

upstream raw materials:

2-(iodomethyl)isoindoline-1,3-dione

2,4-dichloro-6-diiodomethyl-[1,3,5]triazine

8-iodo-3,7-dihydro-purine-2,6-dione

5,7-Diiodoisatin

Downstream raw materials:

2-Iodothiophene

4,4'-bipyridine

3,4,5-triiodo-2-methylthiophene

N-iodo-succinimide

Refernces

• 1、 Kratschmer,. "". . p. 546. Retrieved 1885.
• 2、 Dickey et al.. "". . p. 1674. Retrieved 1949.
• 3、 Ganguli,Ganapathi,Gopalakrishnan,Rao. "LOW-TEMPERATURE SYNTHESIS OF NOVEL LAYERED ALKALI METAL-MoO3 BRONZES AND HEXAGONAL BRONZES OF THE TYPE KyW1 - xMoxO3.". . p. 228 - 231. Retrieved 1988.
• 4、 Janczak, Jan,Idemori, Ynara Marina. "Synthesis, characterisation and structural investigations of iodine-doped indium(III) and zirconium(IV) diphthalocyanines: [InPc2]I2 and [ZrPc2]I2". . p. 85 - 93. Retrieved 2001.
• 5、 Cochran et al.. "". . p. 2145,2147. Retrieved 1954.
• 6、 Lampe,Noyes. "". . p. 2140. Retrieved 1954.
• 7、 Caley, E. R.,Burford, M. G.. "". . p. 114 - 118. Retrieved 1936.
• 8、 Stephan, K. H.,Comes, F. J.. "LASER INDUCED REACTION OF I(2P1/2) YIELDING I2(B3Πou+)". . p. 259 - 262. Retrieved 1980.
• 9、 Green, Mino,Kuku, Titilayo A.. "". . p. 999 - 1008. Retrieved 1983.
• 10、 Taube. "". . p. 161. Retrieved 1942.