4-[[4-[(AMinoiMinoMethyl)aMino]benzoyl]oxy]benzeneacetic Acid

Base Information

• Chemical Name: 4-[[4-[(AMinoiMinoMethyl)aMino]benzoyl]oxy]benzeneacetic Acid
• CAS No.: 71079-08-8
• Molecular Formula: C₁₆H₁₅N₃O₄
• Molecular Weight: 313.313
• Mol file: 71079-08-8.mol

Synonyms:4-(4-guanidinobenzoyloxy)phenylacetic acid

Chemical Property of 4-[[4-[(AMinoiMinoMethyl)aMino]benzoyl]oxy]benzeneacetic Acid

Chemical Property:

• Boiling Point: 537.5±60.0 °C(Predicted)
• PKA: 4.16±0.10(Predicted)
• Density: 1.36±0.1 g/cm3(Predicted)
• Solubility.: DMSO, DMF

Purity/Quality:

99% ^*data from raw suppliers

4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneaceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneacetic Acid is a metabolite of Camostat (C150300), a pollen protease inhibitor for prevention and control of allergy.

Technology Process of 4-[[4-[(AMinoiMinoMethyl)aMino]benzoyl]oxy]benzeneacetic Acid

There total 4 articles about 4-[[4-[(AMinoiMinoMethyl)aMino]benzoyl]oxy]benzeneacetic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

camostat mesylate (59721-29-8) → 4-guanidinobenzoic acid (16060-65-4) + 4-(4-guanidinobenzoyloxy)phenylacetic acid (71079-08-8)

Guidance literature:

With porcine esterase; sodium phosphate buffer; at 37 ℃; Kinetics; pH 7.0;

DOI:10.1248/cpb.36.2544

Reference yield:

→ 4-(4-guanidinobenzoyloxy)phenylacetic acid (71079-08-8) + FOY-251 (71079-09-9)

Guidance literature:

Reference yield:

camostat mesylate (59721-29-8) → 2-hydroxy-N,N-dimethylacetamide (14658-93-6) + 4-(4-guanidinobenzoyloxy)phenylacetic acid (71079-08-8)

Guidance literature:

With Tris-HCl buffer; human liver carboxylesterase pI 5.3; at 37 ℃; pH=7.4; Enzyme kinetics;

DOI:10.1248/bpb.20.869

upstream raw materials:

camostat mesylate

Refernces

• 1、 Nishihata,Saitoh,Sakai. "Intestinal absorption of N,N'-dimethylcarbamoylmethyl 4-(4-guanidinobenzoyloxy) phenylacetate methanesulfonate in rats". . p. 2544 - 2550. Retrieved 2007/10/02.