3-phenyl-1-(phenylmethyl)-1H-pyrrole-2,5-dione

Base Information

• Chemical Name: 3-phenyl-1-(phenylmethyl)-1H-pyrrole-2,5-dione
• CAS No.: 15093-83-1
• Molecular Formula: C₁₇H₁₃NO₂
• Molecular Weight: 263.296
• Mol file: 15093-83-1.mol

Synonyms:3-phenyl-1-(phenylmethyl)-1H-pyrrole-2,5-dione

Chemical Property of 3-phenyl-1-(phenylmethyl)-1H-pyrrole-2,5-dione

Chemical Property:

Purity/Quality:

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Technology Process of 3-phenyl-1-(phenylmethyl)-1H-pyrrole-2,5-dione

There total 6 articles about 3-phenyl-1-(phenylmethyl)-1H-pyrrole-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

carbon monoxide (201230-82-2) + phenylacetylene (536-74-3) + benzylamine (100-46-9) → 3-phenyl-1-(phenylmethyl)-1H-pyrrole-2,5-dione (15093-83-1)

Guidance literature:

With palladium dichloride; In toluene; at 120 ℃; for 12h; under 15001.5 Torr; Sealed tube; Autoclave;

DOI:10.1039/c8cc05802d

Reference yield: 76.0%

1-benzyl-1H-pyrrole-2,5-dione (1631-26-1) + lithium benzoate (553-54-8) → 3-phenyl-1-(phenylmethyl)-1H-pyrrole-2,5-dione (15093-83-1)

Guidance literature:

With silver tetrafluoroborate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper(II) acetate monohydrate; In tetrahydrofuran; at 120 ℃; for 3h; Sealed tube;

DOI:10.1021/acs.orglett.9b01412

Reference yield: 57.0%

trimethylsilyl cyanide (7677-24-9) + 3-iodo-3-phenylacrylic acid + benzylamine (100-46-9) → 3-phenyl-1-(phenylmethyl)-1H-pyrrole-2,5-dione (15093-83-1)

Guidance literature:

With copper(I) oxide; water; at 100 ℃; for 8h; Green chemistry;

DOI:10.1039/d1ob00073j

upstream raw materials:

1-((benzylimino)methyl)-2,2-dichloro-1-phenylcyclopropane

1-benzyl-1H-pyrrole-2,5-dione

phenylboronic acid

carbon monoxide

Downstream raw materials:

(R)-1-benzyl-3-phenyl-2,5-pyrrolidinedione

Refernces

• 1、 Sherikar, Mahadev Sharanappa,Prabhu, Kandikere Ramaiah. "Weak Coordinating Carboxylate Directed Rhodium(III)-Catalyzed C-H Activation: Switchable Decarboxylative Heck-Type and [4 + 1] Annulation Reactions with Maleimides". supporting information. p. 4525 - 4530. Retrieved 2019/06/24.
• 2、 Komeyama, Kimihiro,Kashihara, Tetsuya,Takaki, Ken. "FeSO4-promoted direct arylation of benzoquinones with ArB(OH)2 or ArBF3K". supporting information. p. 1084 - 1086. Retrieved 2013/04/10.