Propionohydrazide

Base Information

• Chemical Name: Propionohydrazide
• CAS No.: 5818-15-5
• Molecular Formula: C3H8N2O
• Molecular Weight: 88.1093
• Hs Code.: 2928000090
• European Community (EC) Number: 227-390-7
• NSC Number: 28448
• UNII: K4H0YVF8J4
• DSSTox Substance ID: DTXSID60206905
• Nikkaji Number: J60.736C
• Wikidata: Q83080779
• Mol file: 5818-15-5.mol

Synonyms:Propionohydrazide;5818-15-5;Propionic acid hydrazide;propanehydrazide;propanoic acid hydrazide;propanohydrazide;Propanoic acid, hydrazide;Propanoic hydrazide;Propiohydrazide;Propionylhydrazide;PROPIONYLHYDRAZINE;Propionic acid, hydrazide;Propanoic acid, hydrazide (9CI);Propionsaeurehydrazid;Propionsaeurehydrazid [German];EINECS 227-390-7;NSC 28448;BRN 0506227;K4H0YVF8J4;NSC-28448;3-02-00-00551 (Beilstein Handbook Reference);N-propionylhydrazine;2-propionylhydrazine;PROPIONIC HYDRAZIDE;N-PROPANOYLHYDRAZINE;UNII-K4H0YVF8J4;DTXSID60206905;NSC28448;BBL036933;MFCD01333200;STK346980;AKOS000104280;PB26058;Propanoic acid hydrazide, >=90% (GC);LS-01216;LS-124690;BB 0237580;CS-0206618;FT-0678555;EN300-04114;J-524055;Z56886418

Chemical Property of Propionohydrazide

Chemical Property:

• Vapor Pressure: 0.0324mmHg at 25°C
• Melting Point: 179-180 °C
• Refractive Index: 1.44
• Boiling Point: 243.3 °C at 760 mmHg
• PKA: 13.46±0.18(Predicted)
• Flash Point: 100.9 °C
• PSA: 55.12000
• Density: 1.005 g/cm³
• LogP: 0.47750
• XLogP3: -0.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 88.063662883
• Heavy Atom Count: 6
• Complexity: 52.8

Purity/Quality:

98%,99%, ^*data from raw suppliers

Propanohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,T
• Hazard Codes: Xi,T
• Statements: 25-36/37/38
• Safety Statements: 26-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(=O)NN

Technology Process of Propionohydrazide

There total 9 articles about Propionohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)propanamide (19162-43-7) → 2-amino-1H-benzo[de]isoquinoline-1,3(2H)-dione (5690-46-0) + d'hydrazide de l'acide propionique (5818-15-5)

Guidance literature:

With hydrazine hydrate; In ethanol; for 3h; Reflux;

DOI:10.1002/chem.202102593

Reference yield: 82.0%

propionic acid (802294-64-0,79-09-4) → d'hydrazide de l'acide propionique (5818-15-5)

Guidance literature:

With hydrazine hydrate; for 0.025h; Microwave irradiation;

Reference yield: 65.0%

propanoic acid methyl ester (554-12-1) → d'hydrazide de l'acide propionique (5818-15-5)

Guidance literature:

With hydrazine hydrate; for 5h; Heating;

DOI:10.1016/S0968-0896(02)00611-9

upstream raw materials:

Ethyl propionate

Propionamid

propanoic acid methyl ester

diethyl ether

Downstream raw materials:

2-n-Propyl-1,3,4-thiadiazol-5-thiol

N-cyclohexylpropanamide

Propionic acid [1-(4-nitro-phenyl)-meth-(E)-ylidene]-hydrazide

Propionic acid [1-(4-chloro-phenyl)-meth-(E)-ylidene]-hydrazide

Refernces

• 1、 Wang, Yi-Jie,Zhang, Guo-Yu,Shoberu, Adedamola,Zou, Jian-Ping. "Iron-catalyzed oxidative amidation of acylhydrazines with amines". supporting information. . Retrieved 2021/08/18.
• 2、 Chen, Danqi,Chen, Yuehong,Lian, Fulin,Chen, Liu,Li, Yanlian,Cao, Danyan,Wang, Xin,Chen, Lin,Li, Jian,Meng, Tao,Huang, Min,Geng, Meiyu,Shen, Jingkang,Zhang, Naixia,Xiong, Bing. "Fragment-based drug discovery of triazole inhibitors to block PDEδ-RAS protein-protein interaction". . p. 597 - 609. Retrieved 2019/01/04.