1-(3,4,5-Trimethoxybenzoyl)piperidine

Base Information

• Chemical Name: 1-(3,4,5-Trimethoxybenzoyl)piperidine
• CAS No.: 3704-26-5
• Molecular Formula: C15H21NO4
• Molecular Weight: 279.336
• Hs Code.: 2933399090
• Mol file: 3704-26-5.mol

Synonyms:N-(3,4,5-Trimethoxybenzoyl)piperidine;N-(3.4.5-Trimethoxy-benzoyl)-piperidin;1-(3.4.5-Trimethoxy-benzoyl)-piperdin;3,4,5-Trimethoxy-benzoesaeure-;Piperidine,1-(3,4,5-trimethoxybenzoyl);1-(3,4,5-trimethoxy-benzoyl)-piperidine;

Chemical Property of 1-(3,4,5-Trimethoxybenzoyl)piperidine

Chemical Property:

• Vapor Pressure: 4.3E-08mmHg at 25°C
• Boiling Point: 444.4°C at 760 mmHg
• Flash Point: 222.5°C
• PSA: 48.00000
• Density: 1.133g/cm³
• LogP: 2.27640

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(3,4,5-Trimethoxybenzoyl)piperidine

There total 5 articles about 1-(3,4,5-Trimethoxybenzoyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

carbon monoxide (201230-82-2) + 1-((3,4,5-Trimethoxyphenyl)diazenyl)piperidine → piperidin-1-yl(3,4,5-trimethoxyphenyl)methanone (3704-26-5)

Guidance literature:

With methanesulfonic acid; tris-(o-tolyl)phosphine; palladium dichloride; In tetrahydrofuran; at 70 ℃; for 18h; under 15001.5 Torr; Autoclave; Inert atmosphere;

DOI:10.1021/acs.orglett.5b00603

Reference yield: 58.0%

piperidine (110-89-4) + 3,4,5-trimethoxy-benzaldehyde (86-81-7) → piperidin-1-yl(3,4,5-trimethoxyphenyl)methanone (3704-26-5)

Guidance literature:

piperidine; With carbon dioxide; Green chemistry;

3,4,5-trimethoxy-benzaldehyde; With tert.-butylhydroperoxide; iron(II) chloride tetrahydrate; tetrabutylammomium bromide; In water; acetonitrile; at 60 ℃; for 10h; Inert atmosphere; Green chemistry;

DOI:10.1016/j.tetlet.2015.08.066

Reference yield: 58.0%

piperidine (110-89-4) + 3,4,5-Trimethoxybenzoyl chloride (4521-61-3) → piperidin-1-yl(3,4,5-trimethoxyphenyl)methanone (3704-26-5)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/jacs.1c04363

upstream raw materials:

piperidine

3,4,5-Trimethoxybenzoyl chloride

carbon monoxide

3,4,5-Trimethoxyaniline

Refernces

• 1、 Li, Wanfang,Wu, Xiao-Feng. "N2 extrusion and co insertion: A novel palladium-catalyzed carbonylative transformation of aryltriazenes". supporting information. p. 1910 - 1913. Retrieved 2015/04/27.
• 2、 Kar. "Synthesis and CNS-depressant profile of 3,4,5-trimethoxybenzoyl analogues". . p. 313 - 315. Retrieved 2007/10/02.