2-(2-methoxyethoxy)ethyl 4-amino-3,5-diiodobenzoate

Base Information

• Chemical Name: 2-(2-methoxyethoxy)ethyl 4-amino-3,5-diiodobenzoate
• CAS No.: 862903-80-8
• Molecular Formula: C₁₂H₁₅I₂NO₄
• Molecular Weight: 491.064
• Mol file: 862903-80-8.mol

Synonyms:2-(2-methoxyethoxy)ethyl 4-amino-3,5-diiodobenzoate

Chemical Property of 2-(2-methoxyethoxy)ethyl 4-amino-3,5-diiodobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-(2-methoxyethoxy)ethyl 4-amino-3,5-diiodobenzoate

There total 2 articles about 2-(2-methoxyethoxy)ethyl 4-amino-3,5-diiodobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-(2-methoxyethoxy)ethyl 4-aminobenzoate (49744-35-6) → 2-(2-methoxyethoxy)ethyl 4-amino-3,5-diiodobenzoate (862903-80-8)

Guidance literature:

With iodine; silver sulfate; In ethanol; at 20 ℃; for 1h;

DOI:10.1021/ja0547984

Reference yield:

p-aminoethylbenzoate (94-09-7) → 2-(2-methoxyethoxy)ethyl 4-amino-3,5-diiodobenzoate (862903-80-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / K₂CO₃ / 7 h / 75 - 80 °C

2: 95 percent / I₂; Ag₂SO₄ / ethanol / 1 h / 20 °C

With iodine; potassium carbonate; silver sulfate; In ethanol;

DOI:10.1021/ja0547984

Reference yield: 50.0%

2-(2-methoxyethoxy)ethyl 4-amino-3,5-diiodobenzoate (862903-80-8) + trimethylsilylacetylene (1066-54-2) → 4-amino-3-iodo-5-trimethylsilanylethynyl-benzoic acid 2-(2-methoxy-ethoxy)-ethyl ester (862903-81-9)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; at 58 - 60 ℃; for 18h;

DOI:10.1021/ja0547984

upstream raw materials:

2-(2-methoxyethoxy)ethyl 4-aminobenzoate

p-aminoethylbenzoate

Downstream raw materials:

4-amino-3-iodo-5-trimethylsilanylethynyl-benzoic acid 2-(2-methoxy-ethoxy)-ethyl ester

2-(2-methoxyethoxy)ethyl 4-amino-3-ethynyl-5-iodobenzoate

C₂₈H₃₀I₂N₂O₈

Refernces

• 1、 Kim, Uk-Il,Suk, Jae-Min,Naidu, Veluru Ramesh,Jeong, Kyu-Sung. "Folding and anion-binding properties of fluorescent oligoindole foldamers". experimental part. p. 11406 - 11414. Retrieved 2009/12/01.