1-phenyl-1-(4-methylphenylthio)propane

Base Information

• Chemical Name: 1-phenyl-1-(4-methylphenylthio)propane
• CAS No.: 107805-98-1
• Molecular Formula: C₁₆H₁₈S
• Molecular Weight: 242.385
• Mol file: 107805-98-1.mol

Synonyms:1-phenyl-1-(4-methylphenylthio)propane

Chemical Property of 1-phenyl-1-(4-methylphenylthio)propane

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 1-phenyl-1-(4-methylphenylthio)propane

There total 4 articles about 1-phenyl-1-(4-methylphenylthio)propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

α-ethyl-N,N-dimethylbenzenemethanamine (3330-05-0) + para-thiocresol (106-45-6) → 1-phenyl-1-(4-methylphenylthio)propane (107805-98-1)

Guidance literature:

With tetrakis(acetonitrile)copper(I) hexafluorophosphate; potassium carbonate; methyl trifluoromethanesulfonate; In 1,4-dioxane; at 110 ℃; for 20h; stereospecific reaction;

DOI:10.1021/acscatal.8b03032

Reference yield: 90.0%

1-phenylpropene (637-50-3) + para-thiocresol (106-45-6) → 1-phenyl-1-(4-methylphenylthio)propane (107805-98-1)

Guidance literature:

With toluene-4-sulfonic acid; zinc(II) iodide; In dichloromethane; at 20 ℃; for 18h; regioselective reaction;

DOI:10.1021/acs.joc.0c00487

Reference yield: 79.0%

4-tolyl iodide (624-31-7) + (R)-1-phenyl-1-propanol (1565-74-8) → 1-phenyl-1-(4-methylphenylthio)propane (107805-98-1)

Guidance literature:

With Lawessons reagent; copper(l) iodide; potassium carbonate; In diethylene glycol dimethyl ether; at 120 ℃; for 20h; Inert atmosphere;

DOI:10.1002/ejoc.201500256

upstream raw materials:

cyclopropylbenzene

para-thiocresol

4-tolyl iodide

(R)-1-phenyl-1-propanol

Refernces

• 1、 Taniguchi, Nobukazu. "Br?nsted Acid-Assisted Zinc-Catalyzed Markovnikov-Type Hydrothiolation of Alkenes Using Thiols". . p. 6528 - 6534. Retrieved 2020/07/14.
• 2、 Shabarov, Yu. S.,Saginova, L. G.,Veselovskaya, S. V.. "REACTION OF ARYLCYCLOPROPANES WITH THIOPHENOLS UNDER ACID CATALYSIS CONDITIONS". . p. 685 - 689. Retrieved 2007/10/02.