Potassium orotate

Base Information

• Chemical Name: Potassium orotate
• CAS No.: 24598-73-0
• Molecular Formula: C5H3KN2O4
• Molecular Weight: 194.188
• Hs Code.: 2933599090
• Mol file: 24598-73-0.mol

Synonyms:4-Pyrimidinecarboxylicacid, 1,2,3,6-tetrahydro-2,6-dioxo-, monopotassium salt (9CI);Orotic acid,monopotassium salt (8CI);Ba 2658;Dioron;Oropur;Orotic acid potassium salt;Uracil-4-carboxylic acid potassium salt;

Chemical Property of Potassium orotate

Chemical Property:

• Appearance/Colour: A white to almost white powder
• PSA: 105.85000
• Density: 2.3534
• LogP: -2.57330
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: Aqueous Base (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

Orotic acid potassium salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Orotic acid (OA) is an intermediate in de novo pyrimidine biosynthesis that may be used to study the specificity and kinetics of orotate phosphoribosyltransferase (OPRT) which catalyzes the reversible phosphoribosyl transfer from 5′-phospho-α-d-ribose 1′-diphosphate (PRPP) to orotic acid (OA), forming pyrophosphate and orotidine 5′-monophosphate (OMP). Orotic acid is used as a starting material for the potential commercial bioproduction of uridine 5′-monophosphate (UMP) by microbes such as Corynebacterium ammoniagenes (ATCC 6872) or Saccharomyces cerevisiae. OA may be used to study the AMPK/SREBP-1 dependent cell signaling pathway and transcription regulation mechanisms that induce hepatic lipogenesis.

Technology Process of Potassium orotate

There total 1 articles about Potassium orotate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

orotic acid (65-86-1,58915-47-2,6784-70-9) → potassium hydroorotate (24598-73-0)

Guidance literature:

With potassium hydroxide; In water;

DOI:10.1039/b110386p

Reference yield:

zinc(II) nitrate hexahydrate + 1,4-bis(imidazol-l-yl-methyl)benzene (56643-83-5) + water (7732-18-5) + potassium hydroorotate (24598-73-0) → {[Zn(Or)(Bimb)(H2O)]2·6H2O}n

Guidance literature:

In methanol; at 20 ℃;

DOI:10.1016/j.poly.2022.115693

Reference yield:

potassium hydroorotate (24598-73-0) → 2,6-dichloro-4-pyrimidinecarboxylic acid (16492-28-7)

Guidance literature:

With N,N-dimethyl-aniline; trichlorophosphate; Reflux;

DOI:10.1002/anie.200904188

upstream raw materials:

orotic acid

Downstream raw materials:

2,6-dichloro-4-pyrimidinecarboxylic acid

Refernces