Dipyrone

Base Information

• Chemical Name: Dipyrone
• CAS No.: 68-89-3
• Molecular Formula: C13H16N3NaO4S
• Molecular Weight: 333.344
• Hs Code.: 29331920
• Mol file: 68-89-3.mol

Synonyms:Dipyrone(6CI);Methanesulfonic acid, (antipyrinylmethylamino)-, sodium salt (8CI);ARPF;Optalgin;Pyralgine;Pyretin;Sodium1-phenyl-2,3-dimethyl-5-pyrazolone-4-methylaminomethanesulfonate;Sodium noramidopyrine methanesulfonate;Sulpin;Sulpyrine;Algopyrin;Anador;Analgin;Andolor;Conmel;Diprofarn;Metamizol;Metamizole sodium;Metamizole sodium salt;Methamizole sodium;Metilon;Neo-melubrine;Noramidopyrine methanesulfonatesodium;Noraminophenazone sodium mesylate;Novalgetol;Novamidazophen;Novaminsulfone;Novaminsulfonium;Noveltex;

Chemical Property of Dipyrone

Chemical Property:

• Appearance/Colour: solid
• Melting Point: 187oC
• PSA: 95.75000
• Density: 1.388 g/cm3
• LogP: 1.50410
• Storage Temp.: 2-8°C
• Solubility.: DMSO (Slightly), Methanol (Slightly), Water (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

Dipyrone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 42/43
• Safety Statements: 36

MSDS Files:

SDS file from LookChem

Useful:

• Description: Dipyrone is a water soluble pyrazolone derivative available in oral, rectal and injectable forms. It has analgesic, antipyretic, antispasmodic, and anti-inflammatory properties. Dipyrone is used most commonly to treat severe pain, particularly, for pain associated with smooth muscle spasm or colic affecting the gastrointestinal, biliary or urinary tracts. It is useful for fever that is refractory to other treatment. Because of the risk of serious adverse effects, such as agranulocytosis, its use is justified only in serious situations where no alternative is available or suitable.
• Uses: It has the effect of detoxification, analgesic and anti-rheumatic etc and mainly used for cooling, but also can be applied to cure the acute arthritis, rheumatic pain, muscle pain and headache etc. A non-steroidal anti-inflammatory drug that, when coadministered with morphine, potentiates its antinociceptive action and delays the development of tolerance. Dipyrone is a relatively selective inhibitor of cyclooxygenase-3 (COX-3), with lower activity against COX-1 and no activity against COX-2. Blocks PGE2-induced hyperalgesia in several models. Dipyrone is a non-steroidal anti-inflammatory drug that, when coadministered with morphine, potentiates its antinociceptive action and delays the development of tolerance. Dipyrone is a relatively sel ective inhibitor of cyclooxygenase-3 (COX-3), with lower activity against COX-1 and no activity against COX-2. Dipyrone blocks PGE2-induced hyperalgesia in several models. Methamizole sodium has expressed analgesic and fever-reducing properties and poorly expressed anti-inflammatory action, and is very convenient in cases where high concentrations of drug need to be quickly reached. Methamizole sodium is used for relieving pain of various origins (renal and biliary colic, neuralgia, myalgia, trauma, burns, headaches, and toothaches). Use of this drug may cause allergic reactions, and long-term use may cause granulocytopenia.