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(R)-N-Boc-2-hydroxymethylmorpholine

Base Information Edit
  • Chemical Name:(R)-N-Boc-2-hydroxymethylmorpholine
  • CAS No.:135065-71-3
  • Molecular Formula:C10H19NO4
  • Molecular Weight:217.265
  • Hs Code.:2934999090
  • European Community (EC) Number:815-640-3
  • DSSTox Substance ID:DTXSID20363725
  • Nikkaji Number:J2.595.684B
  • Wikidata:Q72449572
  • Mol file:135065-71-3.mol
(R)-N-Boc-2-hydroxymethylmorpholine

Synonyms:(R)-N-Boc-2-hydroxymethylmorpholine;135065-71-3;(R)-tert-butyl 2-(hydroxymethyl)morpholine-4-carboxylate;tert-butyl (2R)-2-(hydroxymethyl)morpholine-4-carboxylate;(R)-4-Boc-2-hydroxymethyl-morpholine;(R)-2-Hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester;(R)-2-hydroxymethyl-morpholine-4-carboxylic acid tert-butyl ester;(R)-N-Boc-2-(hydroxymethyl)morpholine;MFCD09260605;SCHEMBL553919;DTXSID20363725;BCP26566;AKOS015841571;AC-4296;CS-W003597;TS-00474;AM20080252;EN300-154283;J-006639;(2R)-4-(tert-Butyloxycarbonyl)morpholine-2-methanol;(R)-tert-butyl2-(hydroxymethyl)morpholine-4-carboxylate;(R)-tert-butyl 2-(hydroxymethyl)-morpholine-4-carboxylate;tert-butyl (R)-2-Hydroxymethyl-morpholine-4-carboxylate;1,1-dimethylethyl (2R)-2-(hydroxymethyl)-4-morpholinecarboxylate

Suppliers and Price of (R)-N-Boc-2-hydroxymethylmorpholine
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • (R)-N-Boc-2-hydroxymethylmorpholine
  • 1g
  • $ 110.00
  • SynQuest Laboratories
  • tert-Butyl (2R)-2-(hydroxymethyl)morpholine-4-carboxylate
  • 10 g
  • $ 1287.00
  • SynQuest Laboratories
  • tert-Butyl (2R)-2-(hydroxymethyl)morpholine-4-carboxylate
  • 5 g
  • $ 744.00
  • SynQuest Laboratories
  • tert-Butyl (2R)-2-(hydroxymethyl)morpholine-4-carboxylate
  • 1 g
  • $ 232.00
  • Matrix Scientific
  • (R)-N-Boc-2-Hydroxymethylmorpholine 95+%
  • 1g
  • $ 39.00
  • Matrix Scientific
  • (R)-N-Boc-2-Hydroxymethylmorpholine 95+%
  • 5g
  • $ 148.00
  • Crysdot
  • (R)-tert-Butyl2-(hydroxymethyl)morpholine-4-carboxylate 98%
  • 25g
  • $ 391.00
  • ChemScene
  • (R)-tert-Butyl2-(hydroxymethyl)morpholine-4-carboxylate >97.0%
  • 5g
  • $ 33.00
  • ChemScene
  • (R)-tert-Butyl2-(hydroxymethyl)morpholine-4-carboxylate >97.0%
  • 1g
  • $ 19.00
  • ChemScene
  • (R)-tert-Butyl2-(hydroxymethyl)morpholine-4-carboxylate >97.0%
  • 10g
  • $ 66.00
Total 100 raw suppliers
Chemical Property of (R)-N-Boc-2-hydroxymethylmorpholine Edit
Chemical Property:
  • Appearance/Colour:White crystal 
  • Vapor Pressure:0mmHg at 25°C 
  • Melting Point:60-62ºC 
  • Refractive Index:1.475 
  • Boiling Point:320.7 °C at 760 mmHg 
  • PKA:14.36±0.10(Predicted) 
  • Flash Point:147.8 °C 
  • PSA:59.00000 
  • Density:1.118 g/cm3 
  • LogP:0.55250 
  • Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C 
  • XLogP3:0.1
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:4
  • Rotatable Bond Count:3
  • Exact Mass:217.13140809
  • Heavy Atom Count:15
  • Complexity:224
Purity/Quality:

98%, *data from raw suppliers

(R)-N-Boc-2-hydroxymethylmorpholine *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:CC(C)(C)OC(=O)N1CCOC(C1)CO
  • Isomeric SMILES:CC(C)(C)OC(=O)N1CCO[C@H](C1)CO
  • Uses (R)-N-Boc-2-hydroxymethylmorpholine is used for preparation of inhibitors of Checkpoint Kinase 1 through template screening.
Technology Process of (R)-N-Boc-2-hydroxymethylmorpholine

There total 14 articles about (R)-N-Boc-2-hydroxymethylmorpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With hydrogen; palladium on activated charcoal; In ethanol; at 70 ℃; for 9h;
Guidance literature:
With trimethylamine; In tetrahydrofuran; water monomer; at 0 - 25 ℃; for 10h;
DOI:10.1016/j.ejmech.2022.114251
Guidance literature:
With diborane; In tetrahydrofuran; at 0 - 20 ℃; for 2h;
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