styrene-β-13C-α,β-trans-2H2

Base Information

• Chemical Name: styrene-β-13C-α,β-trans-2H2
• CAS No.: 91230-91-0
• Molecular Formula: C₈H₈
• Molecular Weight: 107.125
• Mol file: 91230-91-0.mol

Synonyms:styrene-β-13C-α,β-trans-2H2

Chemical Property of styrene-β-13C-α,β-trans-2H2

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of styrene-β-13C-α,β-trans-2H2

There total 6 articles about styrene-β-13C-α,β-trans-2H2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetophenone-β-13C (71777-36-1) → styrene-β-13C-α,β-trans-2H2 (91230-91-0)

Guidance literature:

Multi-step reaction with 4 steps

1: PCl₅ / benzene / 5 h / 0 °C

2: NaNH₂ / liquid ammonia; diethyl ether / 3 h / -78 °C

3: 87 percent / D₂O, benzylhexadecyldimethylammonium chloride, NaOD / CH₂Cl₂

4: 2.) n-butyllithium / 1.) irradiation 20 min; 2.) n-butyllithium, hexane, THF, -78 deg C, 4 h 15 min

With n-butyllithium; deuteriated sodium hydroxide; phosphorus pentachloride; water-d2; cetyldimethylbenzylammonium chloride; sodium amide; In diethyl ether; dichloromethane; ammonia; benzene;

DOI:10.1021/ja00330a046

Reference yield:

phenylacetylene-2-13C (54522-92-8) → styrene-β-13C-α,β-trans-2H2 (91230-91-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / D₂O, benzylhexadecyldimethylammonium chloride, NaOD / CH₂Cl₂

2: 2.) n-butyllithium / 1.) irradiation 20 min; 2.) n-butyllithium, hexane, THF, -78 deg C, 4 h 15 min

With n-butyllithium; deuteriated sodium hydroxide; water-d2; cetyldimethylbenzylammonium chloride; In dichloromethane;

DOI:10.1021/ja00330a046

Reference yield:

benzaldehyde (100-52-7) → styrene-β-13C-α,β-trans-2H2 (91230-91-0)

Guidance literature:

Multi-step reaction with 6 steps

1: 1.) tert-butyllithium / 1.) pentane, -78 deg C, 2.45 h; 2.) pentane, ether, -78 deg C, 7 h

2: PCC / CH₂Cl₂

3: PCl₅ / benzene / 5 h / 0 °C

4: NaNH₂ / liquid ammonia; diethyl ether / 3 h / -78 °C

5: 87 percent / D₂O, benzylhexadecyldimethylammonium chloride, NaOD / CH₂Cl₂

6: 2.) n-butyllithium / 1.) irradiation 20 min; 2.) n-butyllithium, hexane, THF, -78 deg C, 4 h 15 min

With n-butyllithium; deuteriated sodium hydroxide; phosphorus pentachloride; water-d2; tert.-butyl lithium; cetyldimethylbenzylammonium chloride; sodium amide; pyridinium chlorochromate; In diethyl ether; dichloromethane; ammonia; benzene;

DOI:10.1021/ja00330a046

upstream raw materials:

phenylacetylene-2-13C-2-2H

triphenylstannane-d₁

acetophenone-β-¹³C

phenylacetylene-2-13C

Downstream raw materials:

(1S,2S,3R)-(+)-2-phenylcyclopropanecarboxylic-3-13C-1,2,3-2H₃ acid

(1R,2S,3R)-phenylcyclopropane-2-13C-1,2,3-2H₃

(1S,2S,3R)-2-phenylcyclopropanemethanol-3-13C-1,2,3-2H₃

Refernces