1,2-Bis(dimethoxyphosphoryl)ethane

Base Information

• Chemical Name: 1,2-Bis(dimethoxyphosphoryl)ethane
• CAS No.: 5927-50-4
• Molecular Formula: C₆H₁₆O₆P₂
• Molecular Weight: 246.137
• Hs Code.: 2931499090
• DSSTox Substance ID: DTXSID40378730
• Nikkaji Number: J3.525.771C
• Wikidata: Q82168282
• Mol file: 5927-50-4.mol

Synonyms:1,2-bis(dimethoxyphosphoryl)ethane;5927-50-4;Tetramethyl ethylenediphosphonate;SCHEMBL4693695;Tetramethylethylenebisphosphonate;DTXSID40378730;MFCD00043868;AKOS017343613;tetramethyl 1,2-ethanediylbisphosphonate;tetramethyl ethane-1,2-diyldiphosphonate;Ethylenebis(phosphonic acid dimethyl) ester;FT-0635907;J3.525.771C

Chemical Property of 1,2-Bis(dimethoxyphosphoryl)ethane

Chemical Property:

• Vapor Pressure: 0.000471mmHg at 25°C
• Refractive Index: 1.416
• Boiling Point: 324.2 °C at 760 mmHg
• Flash Point: 163.7 °C
• PSA: 90.68000
• Density: 1.222 g/cm³
• LogP: 1.95820
• XLogP3: -1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 7
• Exact Mass: 246.04221222
• Heavy Atom Count: 14
• Complexity: 211

Purity/Quality:

98%min ^*data from raw suppliers

TETRAMETHYLETHYLENEBISPHOSPHONATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COP(=O)(CCP(=O)(OC)OC)OC

Technology Process of 1,2-Bis(dimethoxyphosphoryl)ethane

There total 3 articles about 1,2-Bis(dimethoxyphosphoryl)ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

dimethylvinylphosphonate (4645-32-3) + Dimethyl phosphite (868-85-9) → bisphosphorylethane (5927-50-4)

Guidance literature:

With trimethylphosphane; In tetrahydrofuran; at 0 - 25 ℃; for 20.5h; Reagent/catalyst; Solvent; Catalytic behavior; Schlenk technique;

DOI:10.1016/j.tetlet.2015.07.077

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + ethane-1,2-diphosphonic acid (6145-31-9) → bisphosphorylethane (5927-50-4)

Guidance literature:

In diethyl ether;

DOI:10.1071/CH9670503

Reference yield:

→ bisphosphorylethane (5927-50-4)

Guidance literature:

Trimethylphosphit, 1,2-Dibromethan, 170grad; neben Methylphosphonsaeure-dimethylester;

DOI:10.1039/jr9650006638

upstream raw materials:

diazomethane

ethane-1,2-diphosphonic acid

dimethylvinylphosphonate

Dimethyl phosphite

Refernces