Fmoc-Glu(OBzl)-OH

Base Information

• Chemical Name: Fmoc-Glu(OBzl)-OH
• CAS No.: 123639-61-2
• Molecular Formula: C27H25NO6
• Molecular Weight: 459.499
• Hs Code.: 2924 29 70
• European Community (EC) Number: 896-584-7
• DSSTox Substance ID: DTXSID10553436
• Wikidata: Q72478394
• Mol file: 123639-61-2.mol

Synonyms:Fmoc-Glu(OBzl)-OH;123639-61-2;(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-(benzyloxy)-5-oxopentanoic acid;L-Glutamic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 5-(phenylmethyl)ester;(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-5-oxo-5-phenylmethoxypentanoic acid;MFCD00065642;SCHEMBL119479;DTXSID10553436;HJJURMMMGPQIQP-DEOSSOPVSA-N;AMY25324;AKOS015911770;AKOS015924151;CS-W009642;FD21358;HY-W008926;DS-15017;N-a-Fmoc-L-glutamic acid ?-benzyl ester;Fmoc-Glu(OBzl)-OH, >=98.0% (HPLC);EN300-396677;M03411;J-300094;Q-101687;(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-5-oxo-5-(phenylmethoxy)pentanoic acid;(2S)-5-(benzyloxy)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-5-oxopentanoic acid;(S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-5-(benzyloxy)-5-oxopentanoic acid;(2S)-5-(Benzyloxy)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-5-oxopentanoic acid (non-preferred name);N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-glutamic-acid-gamma-benZyl ester (Fmoc-L-Glu(BZl)-OH)

Chemical Property of Fmoc-Glu(OBzl)-OH

Chemical Property:

• Appearance/Colour: White powder
• Vapor Pressure: 1.83E-20mmHg at 25°C
• Melting Point: 80-85 ºC
• Refractive Index: 1.613
• Boiling Point: 698.2 ºC at 760 mmHg
• PKA: 3.70±0.10(Predicted)
• Flash Point: 376.1 ºC
• PSA: 101.93000
• Density: 1.289 g/cm³
• LogP: 4.89280
• Storage Temp.: 2-8°C
• XLogP3: 4.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 11
• Exact Mass: 459.16818752
• Heavy Atom Count: 34
• Complexity: 683

Purity/Quality:

99% ^*data from raw suppliers

Fmoc-glu(obzl)-oh ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC(=O)CCC(C(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24
• Isomeric SMILES: C1=CC=C(C=C1)COC(=O)CC[C@@H](C(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24
• Uses: Fmoc-glu(obzl)-oh, is an amino acid derivative used in chemical synthesis and peptide chemistry.

Technology Process of Fmoc-Glu(OBzl)-OH

There total 4 articles about Fmoc-Glu(OBzl)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

→ Fmoc-L-glutamic acid-g-benzyl ester (123639-61-2)

Guidance literature:

Reference yield:

γ-benzyl glutamate + fluorenylmethyloxycarbonyl chloride → Fmoc-L-glutamic acid-g-benzyl ester (123639-61-2)

Guidance literature:

With triethylamine; In 1,4-dioxane; water;

Reference yield:

γ-benzyl glutamate + fluorenylmethyloxycarbonyl chloride + cholesterol (57-88-5) → Fmoc-L-glutamic acid-g-benzyl ester (123639-61-2)

Guidance literature:

With triethylamine; In 1,4-dioxane; water;

upstream raw materials:

cholesterol

Downstream raw materials:

FMOC-Glu(OBn)-Cl

benzyl (S)-4-(((9H-fluoren-9-yl)methoxy)carbonyl)amino-5-iodopentanoate

Refernces

• 1、 -. "PEPTIDE NUCLEIC ACID CONJUGATES". . . Retrieved 2008/06/13.
• 2、 -. "Pyrrolidine-containing monomers and oligomers". . . Retrieved 2008/06/13.