H-D-CIT-OH

Base Information

• Chemical Name: H-D-CIT-OH
• CAS No.: 13594-51-9
• Molecular Formula: C6H13N3O3
• Molecular Weight: 175.19
• Hs Code.: 2924199090
• Mol file: 13594-51-9.mol

Synonyms:Ornithine,N⁵-carbamoyl-, D- (8CI);NSC 206276;(R)-2-Amino-5-ureidopentanoic acid;

Chemical Property of H-D-CIT-OH

Chemical Property:

• Appearance/Colour: White powder
• Vapor Pressure: 4.7E-07mmHg at 25°C
• Melting Point: 220-221 °C
• Refractive Index: 1.531
• Boiling Point: 386.694 °C at 760 mmHg
• PKA: 2.51±0.24(Predicted)
• Flash Point: 187.666 °C
• PSA: 118.44000
• Density: 1.289 g/cm³
• LogP: 0.63830
• Storage Temp.: −20°C

Purity/Quality:

98%min ^*data from raw suppliers

D-Citrulline 99+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-D-CIT-OH

There total 7 articles about H-D-CIT-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

L-Citrullinhydantoin (133906-52-2) → D-citrulline (13594-51-9)

Guidance literature:

With sodium hydroxide; In water; 1.) Agrobacterium radiobacter, 40 deg C, 24 h, 6 bar, 2.) 40 deg C, 24 h;

Reference yield:

nitrourea (556-89-8) + L-ornithine hydrochloride (3184-13-2,36630-89-4) → 2-Amino-5-ureido-pentanoic acid (372-75-8,627-77-0,7005-93-8,13594-51-9)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1021/jo00295a022

Reference yield:

L-ornithine (70-26-8,25104-12-5,410523-47-6) → D-citrulline (13594-51-9)

Guidance literature:

Multi-step reaction with 3 steps

2: pH 1

3: 85 percent / NaOH, Agrobacterium radiobacter / H₂O / other substrates

With sodium hydroxide; Agrobacterium radiobacter; In water;

upstream raw materials:

D-ornithine

potassium cyanide

L-Citrullinhydantoin

urea

Downstream raw materials:

N^α-(benzyloxycarbonyl)-L-citrulline

(S)-2-((S)-2-((((9H-fluoren-9-yl)-methoxy)carbonyl)amino)-3-methylbutanamido)-5-ureidopentanoic acid

α-(benzyloxycarbonyl)arginino>succinic acid trimethyl ester

2-Benzyloxycarbonylamino-5-(2-imino-4-methoxycarbonylmethyl-5-oxo-imidazolidin-1-yl)-pentanoic acid methyl ester

Refernces

• 1、 Ranganathan,Rathi. "Urea cycle: Chemical simulation of arginine biosynthesis". . p. 2351 - 2354. Retrieved 2007/10/02.