Boc-Asn(Xan)-OH

Base Information

• Chemical Name: Boc-Asn(Xan)-OH
• CAS No.: 65420-40-8
• Molecular Formula: C22H24N2O6
• Molecular Weight: 412.442
• Hs Code.: 29329990
• European Community (EC) Number: 685-350-8
• Mol file: 65420-40-8.mol

Synonyms:Boc-Asn(Xan)-OH;65420-40-8;N-Boc-N'-xanthyl-L-asparagine;N-Alpha-t-Boc-N-beta-xanthyl-L-asparagine;N-ALFA-BOC-N-GAMMA-XANTHYL-L-ASPARAGINE;(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-4-oxo-4-(9H-xanthen-9-ylamino)butanoic acid;N2-(tert-Butoxycarbonyl)-N4-(9H-xanthen-9-yl)-L-asparagine;AMY25341;MFCD00066157;AKOS016008669;FD21157;AS-48978;CS-0136341;Nalpha-Boc-Nbeta-xanthenyl-L-asparagine, 96%;Boc-Asn(Xan)-OH, >=98.0% (sum of enantiomers, TLC);L-Asparagine, N2-[(1,1-dimethylethoxy)carbonyl]-N-9H-xanthen-9-yl-;N-alpha-t-Butyloxycarbonyl-L-N-beta-xantyl-asparagine (Boc-L-Asn(Xan)-OH)

Chemical Property of Boc-Asn(Xan)-OH

Chemical Property:

• Appearance/Colour: White to off white powder
• Vapor Pressure: 8.06E-18mmHg at 25°C
• Melting Point: 177.5-181.5 °C
• Refractive Index: 1.614
• Boiling Point: 650.7 °C at 760 mmHg
• PKA: 3.93±0.10(Predicted)
• Flash Point: 347.3 °C
• PSA: 113.96000
• Density: 1.32 g/cm³
• LogP: 4.14770
• Storage Temp.: 2-8°C
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 7
• Exact Mass: 412.16343649
• Heavy Atom Count: 30
• Complexity: 624

Purity/Quality:

99% ^*data from raw suppliers

Boc-Asn(Xan)-OH Novabiochem? ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NC(CC(=O)NC1C2=CC=CC=C2OC3=CC=CC=C13)C(=O)O
• Isomeric SMILES: CC(C)(C)OC(=O)N[C@@H](CC(=O)NC1C2=CC=CC=C2OC3=CC=CC=C13)C(=O)O
• Uses: Boc-Asn(Xan)-OH, is an Asparagine derivative, used in various chemical synthesis and biology studies.

Technology Process of Boc-Asn(Xan)-OH

There total 1 articles about Boc-Asn(Xan)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

9-hydroxyxanthene (90-46-0) + N-tert-butyloxycarbonylasparagine (7536-55-2) → (S)-2-tert-Butoxycarbonylamino-N-(9H-xanthen-9-yl)-succinamic acid (65420-40-8)

Guidance literature:

In acetic acid; for 63h; Ambient temperature;

Reference yield: 94.0%

DL-phenylalanine methyl ester (15028-44-1) + (S)-2-tert-Butoxycarbonylamino-N-(9H-xanthen-9-yl)-succinamic acid (65420-40-8) → methyl N2-(tert-butoxycarbonyl)-N4-(9H-xanthen-9-yl)-L-asparaginyl-phenylalaninate

Guidance literature:

With pyridine; FI-750-M; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In water; at 60 ℃; for 0.166667h; Sealed tube;

DOI:10.1021/acs.orglett.0c01676

Reference yield: 10.7%

BOC-glycine (4530-20-5) + N-(tert-butyloxycarbonyl)-L-isoleucine (13139-16-7) + N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) + L-N-Boc-Ala (15761-38-3) + N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) + Boc-Arg(Tos)-OH (13836-37-8) + BOC-O-benzyl-L-serine (23680-31-1) + Boc-Asp(O-cyclohexyl)-OH (73821-95-1) + Boc-cysteine(4-Me-Bn) (61925-77-7) + Boc-(S)-Lys(2-Cl-Z)-OH (54613-99-9) + N-Boc-4-I-Phe-OH (103882-09-3,62129-44-6) + (S)-2-tert-Butoxycarbonylamino-N-(9H-xanthen-9-yl)-succinamic acid (65420-40-8) → C134H222IN41O40S7

Guidance literature:

Boc-cysteine(4-Me-Bn); mercaptopropionyl-Gly-O-CH₂-phi-CH₂CO-aminomethyl polystyrene resin; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;

With trifluoroacetic acid;

BOC-glycine; N-(tert-butyloxycarbonyl)-L-isoleucine; N-tert-butoxycarbonyl-L-leucine; L-N-Boc-Ala; N-tert-butoxycarbonyl-L-phenylalanine; Boc-Arg(Tos)-OH; BOC-O-benzyl-L-serine; Boc-Asp(O-cyclohexyl)-OH; Boc-(S)-Lys(2-Cl-Z)-OH; N-Boc-4-I-Phe-OH; (S)-2-tert-Butoxycarbonylamino-N-(9H-xanthen-9-yl)-succinamic acid; Further stages;

DOI:10.1002/anie.201602719

upstream raw materials:

9-hydroxyxanthene

N-tert-butyloxycarbonylasparagine

Downstream raw materials:

L-proinsulin(Cys₇₂-Asn₈₆)

cyclo(3-14)H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-D-Tyr-Lys-Thr-Phe-Thr-Ser-Cys-OH

cyclo(3-14)H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Tyr-Lys-Thr-Phe-Thr-Ser-Cys-OH

somatostatin

Refernces