Desmopressin acetate

Base Information

• Chemical Name: Desmopressin acetate
• CAS No.: 16789-98-3
• Molecular Formula: C₂H₄O₂*C₄₆H₆₄N₁₄O₁₂S₂
• Molecular Weight: 1129.29
• Hs Code.: 2937190090
• Mol file: 16789-98-3.mol

Synonyms:Mpr-Tyr-Phe-Gln-Asn-Cys-Pro-D-Arg-Gly-NH2(S-S:1-5);

Chemical Property of Desmopressin acetate

Chemical Property:

• PSA: 560.61000
• Density: 1.563 g/cm³
• LogP: 1.70530
• Storage Temp.: −20°C
• Solubility.: Acetic Acid (Slightly), Methanol (Slightly), Water (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

DesmopressinAcetate(1:2) 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20
• Safety Statements: 36

MSDS Files:

SDS file from LookChem

Useful:

• Clinical Use: Desmopressin, as its acetate salt, is a synthetic analogue of vasopressin in which the Nterminal Cys is devoid of its α-amino function (1-Deamino) and where Arg8 is present as its D-isomer (D-Arg8), thus the commercial acronym DDAVP. The presence of D-Arg and the absence of the N-terminal amine in the desmopressin structure have increased its half-life such that it is available for oral, parenteral, or nasal use. It is used by all three of these routes of administration to prevent or control polydipsia (excessive thirst), polyuria, and dehydration of patients with diabetes insipidus caused by a deficiency of vasopressin. It also has been approved for the treatment of nocturnal enuresis (bed-wetting), which is believed to be caused by an absence of the normal night time rise in vasopressin levels.Desmopressin is known to cause an increase in both plasma factor VIII (antihemophilic factor) and plasminogen activator. It therefore is approved by the U.S. FDA for use, parenterally and nasally, in reducing spontaneous or trauma-induced bleeding episodes in patients with hemophilia A and type I Von Willebrand's disease, provided that their plasma factor VIII activity is greater than 5%. Stimate, the nasal spray used in treating patients with hemophilia A and type I Von Willebrand's disease, is 15-fold the concentration of DDAVP nasal spray; the latter is used in treating diabetes insipidus.

Technology Process of Desmopressin acetate

There total 2 articles about Desmopressin acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

desmopressin trifluoroacetate + acetic acid (64-19-7,77671-22-8) → desmopressin acetate (16789-98-3,62288-83-9)

Guidance literature:

Reference yield:

→ desmopressin acetate (16789-98-3,62288-83-9)

Guidance literature:

upstream raw materials:

acetic acid

Refernces

• 1、 -. "Counterion exchange process for peptides". Page/Page column 10. . Retrieved 2008/06/13.