Thymosin alpha 1

Base Information

• Chemical Name: Thymosin alpha 1
• CAS No.: 62304-98-7
• Molecular Formula: C₁₂₉H₂₁₅N₃₃O₅₅
• Molecular Weight: 3108.31
• Mol file: 62304-98-7.mol

Synonyms:Thymosina1 (ox);L-Asparagine,N-acetyl-L-seryl-L-a-aspartyl-L-alanyl-L-alanyl-L-valyl-L-a-aspartyl-L-threonyl-L-seryl-L-seryl-L-a-glutamyl-L-isoleucyl-L-threonyl-L-threonyl-L-lysyl-L-a-aspartyl-L-leucyl-L-lysyl-L-a-glutamyl-L-lysyl-L-lysyl-L-a-glutamyl-L-valyl-L-valyl-L-a-glutamyl-L-a-glutamyl-L-alanyl-L-a-glutamyl-;Thymalfasin;Thymosina1 (human);Zadaxin;

Chemical Property of Thymosin alpha 1

Chemical Property:

• Appearance/Colour: White powder
• Boiling Point: 2899.7±65.0 °C(Predicted)
• PSA: 1456.35000
• Density: 1.360±0.06 g/cm3(Predicted)
• LogP: -3.64450
• Storage Temp.: −20°C
• Solubility.: It is recommended to reconstitute the lyophilized Thymosin a1 in sterile 18MΩ-cm H2O not less than 100 μg/ml, which can then be further diluted to other aqueous solutions.

Purity/Quality:

95% ^*data from raw suppliers

Thymosin alpha 1 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Thymosin-α1 (T-α1), a synthetic 28-amino acid peptide with multiple biological activities primarily directed towards immune response enhancement, this drug is used for the treatment of HBV and hepatitis C virus (HCV) infections, and being developed for the treatment of non-small cell lung cancer (NSCLC), hepatocellular carcinoma, AIDS and malignant melanoma. T-α1 is able to potentiate the action of cytokines and also reduce the hematological toxicity of cytotoxic drug therapy, such as cyclophosphamide, 5-fluorouracil, dacarbazine. Thymosin α1 is an immunomodulator peptide formed from the cleavage of prothymosin α. Thymosin α1 inhibits the growth of 5TGM1 mouse and OPM-2, LP-1, and U266 human multiple myeloma cells in vitro but not in vivo. It also increases CD3- and CD28-induced T cell proliferation in C57BL/KaLwRij splenocytes but not in allogeneic mixed lymphocyte reactions using C57BL/KaLwRij and BALB/c splenocyte co-cultures when used at a concentration of 20 μM. Thymosin α1 also inhibits the growth and migration of H1299, NL9980, and L9981 non-small cell lung cancer (NSCLC) cells that express high levels of programmed cell death ligand 1 (PD-L1) but not of A549 and SPC-A-1 NSCLC cells that express low PD-L1 levels. It also decreases the number of metastatic lesions in a L9981, but not an A549, NSCLC mouse xenograft model when administered at a dose of 20 mg/kg per day. Thymosin α1 (200 μg/kg) increases indoleamine 2,3-dioxygenase 1 (IDO1) expression and IL-10 levels and decreases IL-1β and TNF-α production in the lung in a p.Phe508del mutant cystic fibrosis transmembrane conductance regulator (CFTRF508del/F508del) mouse model of cystic fibrosis and chronic A. fumigatus infection.
• Uses: Zadax-in (SciClone).Thymosin alpha 1 is a peptide naturally occurring in the thymus that has long been recognized for modifying, enhancing, and restoring immune function. Immune enhancing peptideHelps prevent infections such as the common cold or the flu and diseasesReduces inflammation in the bodyAids in the removal of acute or chronic infectionsHas antibacterial, antiviral, and antifungal propertiesSupports the eradication of unhealthy cellsProtects your cells against oxidative stress and damageInhibits viral replicationImprove symptoms associated with chronic fatigueThymosin alpha 1 has been utilized in the treatment of immunocompromised states and malignancies, as an enhancer of vaccine response, and as a means of curbing morbidity and mortality in sepsis and numerous infections. https://www.ncbi.nlm.nih.gov
• Biological Functions: Thymalfasin is a synthetic analogue of thymosin-alpha-1, a 28-amino acid protein derived from the precursor protein prothymosin-alpha. Exhibiting a variety of immunoregulating properties, thymosin-alpha-1 induces differentiation of murine T-cell precursors and human thymocytes and the terminal differentiation of functionally immature cord blood lymphocytes and induces production of IL-2, high affinity IL-2 receptors, and B-cell growth factors by peripheral blood mononuclear cells. T-helper and cytotoxic/suppressor T-cell populations are targets of thymosin activity. Thymosin-alpha-1 has been shown to increase the efficiency of antigen presentation by macrophages and to be an endogenous modulator of alpha-thrombin activity.https://www.prospecbio.com

Technology Process of Thymosin alpha 1

There total 1 articles about Thymosin alpha 1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ thymosin α1 (62304-98-7,69440-99-9)

Guidance literature:

Refernces