trans-2-Aminocyclopentanol hydrochloride

Base Information

• Chemical Name: trans-2-Aminocyclopentanol hydrochloride
• CAS No.: 68327-11-7
• Molecular Formula: C5H12ClNO
• Molecular Weight: 137.609
• Hs Code.: 29221990
• European Community (EC) Number: 802-195-5
• ChEMBL ID: CHEMBL2374489
• Mol file: 68327-11-7.mol

Synonyms:68327-11-7;(1R,2R)-2-aminocyclopentanol hydrochloride;31775-67-4;trans-2-Aminocyclopentanol hydrochloride;trans-(1R,2R)-2-Aminocyclopentanol hydrochloride;Trans-(-)-2-aminocyclopentanol hydrochloride;(1R,2R)-2-aminocyclopentan-1-ol hydrochloride;(1R,2R)-2-aminocyclopentan-1-ol;hydrochloride;(1R,2R)-rel-2-Aminocyclopentanol hydrochloride;MFCD09834692;(1R,2R)-2-Aminocyclopentanol, HCl;trans-2-amino-cyclopentanol hydrochloride;(1R,2R)-2-Aminocyclopentan-1-ol HCl;rel-(1R,2R)-2-Aminocyclopentanol hydrochloride;(1R,2R)-trans-2-Aminocyclopentanol hydrochloride;Cyclopentanol, 2-amino-, hydrochloride, (1R,2R)-;MFCD02683551;SCHEMBL285952;trans-2-Aminocyclopentanol HCl;CHEMBL2374489;ZFSXKSSWYSZPGQ-TYSVMGFPSA-N;(1R,2R)-2-aminocyclopentanol hcl;BCP12204;AC-973;AKOS015849508;AKOS015894235;trans-2-Aminocyclopentanolhydrochloride;AM84914;CS-W008557;trans 2-aminocyclopentanol hydrochloride;(1R,2R)-trans-2-Aminocyclopentanol HCl;DS-11273;(r,r)-2-amino-1-cyclopentanol hydrochloride;EN300-60314;EN300-251517;(1R,2R)-2-amino-1-cyclopentanol hydrochloride;(1R,2R)-2-azanylcyclopentan-1-ol hydrochloride;A820983;A836106;A854841;(1R,2R)-2-Amino-cyclopentanol hydrochloride, 99%;(1R,2R)-2-Aminocyclopentanol hydrochloride (1:1);J-500286;rac-(1R,2R)-2-aminocyclopentan-1-ol hydrochloride;Trans-(1R,2R)-2-Amino-Cyclopentanol Hydrochloride;(1R,2R)-2-Amino-1-hydroxycyclopentane Hydrochloride;(1R,2R)-trans-2-Aminocyclopentanol hydrochloride, 97%;Z2256393934;(1R,2R)-(-)-2-hydroxycyclopentylamine hydrochloride salt;trans-(1R,2R)-2-Aminocyclopentanol Hydrochloride

Chemical Property of trans-2-Aminocyclopentanol hydrochloride

Chemical Property:

• Melting Point: 191-196 °C(lit.)
• Boiling Point: 220.9 °C at 760 mmHg
• Flash Point: 87.4 °C
• PSA: 46.25000
• LogP: 1.36080
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 137.0607417
• Heavy Atom Count: 8
• Complexity: 65.1

Purity/Quality:

98% ^*data from raw suppliers

(1R,2R)-2-Aminocyclopentanol Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(C(C1)O)N.Cl
• Isomeric SMILES: C1C[C@H]([C@@H](C1)O)N.Cl
• Uses: (1R,2R)-2-Aminocyclopentanol hydrochloride is a useful research chemical.

Technology Process of trans-2-Aminocyclopentanol hydrochloride

There total 4 articles about trans-2-Aminocyclopentanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+/-)-2-(4-nitro-phenyl)-(3ar,6ac)-4,5,6,6a-tetrahydro-3aH-cyclopentoxazole (16936-83-7,18721-47-6,33092-75-0) → cis-aminotetrahydro-3-furanol hydrochloride (31775-67-4,31889-37-9,33092-89-6,68327-04-8,68327-11-7,98137-42-9,137254-03-6)

Guidance literature:

With hydrogenchloride; water;

DOI:10.1021/ja01161a089

Reference yield:

trans-2-aminocyclopentanol (33092-86-3) → cis-aminotetrahydro-3-furanol hydrochloride (31775-67-4,31889-37-9,33092-89-6,68327-04-8,68327-11-7,98137-42-9,137254-03-6)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂O; benzene; aq. NaOH solution

2: SOCl₂

3: water; HCl

With hydrogenchloride; sodium hydroxide; thionyl chloride; water; benzene;

DOI:10.1021/ja01161a089

Reference yield:

(+/-)-4-nitro-benzoic acid-(trans-2-hydroxy-cyclopentylamide) (33092-88-5,100135-54-4) → cis-aminotetrahydro-3-furanol hydrochloride (31775-67-4,31889-37-9,33092-89-6,68327-04-8,68327-11-7,98137-42-9,137254-03-6)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂

2: water; HCl

With hydrogenchloride; thionyl chloride; water;

DOI:10.1021/ja01161a089

upstream raw materials:

(+/-)-2-(4-nitro-phenyl)-(3ar,6ac)-4,5,6,6a-tetrahydro-3aH-cyclopentoxazole

trans-2-aminocyclopentanol

(+/-)-4-nitro-benzoic acid-(trans-2-hydroxy-cyclopentylamide)

Downstream raw materials:

6-((1R,2R)-2-hydroxycyclopentylamino)-5-methyl-3-(phenylamino)-2H-pyrazolo[3,4-d]pyrimidin-4(5H)-one

(1R,2R)-trans-2-(tertbutoxycarbonylamino)cyclopentanol