Fomepizole

Base Information Edit

Chemical Name:Fomepizole
CAS No.:7554-65-6
Molecular Formula:C4H6N2
Molecular Weight:82.105
Hs Code.:29331990
European Community (EC) Number:231-445-0
NSC Number:760365
UNII:83LCM6L2BY
DSSTox Substance ID:DTXSID3040649
Nikkaji Number:J35.396E
Wikipedia:Fomepizole
Wikidata:Q416410
NCI Thesaurus Code:C47538
RXCUI:15226
Pharos Ligand ID:13CLBGGWJ5GB
Metabolomics Workbench ID:43426
ChEMBL ID:CHEMBL1308
Mol file:7554-65-6.mol

Synonyms:4 Methylpyrazole;4 Methylpyrazole Monohydrochloride;4-methylpyrazole;4-methylpyrazole monohydrochloride;Antizol;fomepizole

Suppliers and Price of Fomepizole

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Fomepizole
1g
$ 326.00

TRC
Fomepizole
25g
$ 820.00

TRC
Fomepizole
5g
$ 225.00

TRC
Fomepizole
1g
$ 55.00

TCI Chemical
4-Methylpyrazole >98.0%(GC)
1g
$ 84.00

TCI Chemical
4-Methylpyrazole >98.0%(GC)
5g
$ 255.00

SynQuest Laboratories
4-Methylpyrazole 98%
500 g
$ 320.00

SynQuest Laboratories
4-Methylpyrazole 98%
25 g
$ 31.00

SynQuest Laboratories
4-Methylpyrazole 98%
100 g
$ 80.00

Sigma-Aldrich
Fomepizole 99%
1g
$ 106.00

Total 128 raw suppliers

Chemical Property of Fomepizole Edit

Chemical Property:

Appearance/Colour:clear colourless to yellowish liquid after melting
Vapor Pressure:0.0497mmHg at 25°C
Melting Point:13°C
Refractive Index:n20/D 1.495(lit.)
Boiling Point:243.6 °C at 760 mmHg
PKA:14.95±0.50(Predicted)
Flash Point:96.1 °C
PSA：28.68000
Density:1.062 g/cm³
LogP:0.71810
Storage Temp.:2-8°C
Sensitive.:Hygroscopic
Solubility.:soluble
Water Solubility.:soluble
XLogP3:1.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:0
Exact Mass:82.053098200
Heavy Atom Count:6
Complexity:44.8

Purity/Quality:

99% ^*data from raw suppliers

Fomepizole ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22-36/37/38
Safety Statements: 26-36-24/25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CNN=C1
Recent ClinicalTrials:Specified Drug-use Survey of Fomepizole Intravenous Infusion (All-case Surveillance)
Recent NIPH Clinical Trials:None
Description Fomepizole is the first drug indicated as an antidote for ethylene glycol poisoning (it has also shown promise as a treatment for methanol poisoning). Fomepizole is 4-methyl-1H-pyrazole active as a synthetic alcohol dehydrogenase inhibitor, blocking the formation of toxic ethylene glycol metabolites which are responsible for a severe metabolic acidosis and renal failure. In limited human studies, it reversed the toxicity of potentially lethal doses of ethylene glycol. The main urinary metabolite has been reported to be 4-carboxypyrazole by oxidation of the methyl group. Compared with the current treatment (ethanol), the duration of action is longer and the safety is improved, with no toxic effects reported. Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes metabolism of ethylene glycol and methanol to toxic metabolites. At 10 μM in monkeys, it can prevent the formation of toxic alcohol metabolites that generate metabolic acidosis. This compound is typically used as an antidote for ethylene glycol or methanol poisoning.
Uses Useful as an antidote in methanol and ethylene glycol poisoning. Antidote in methanol or ethylene glycol poisoning;Alcohol dehydrogenase inhibitor antidote to ethylene glycol or methanol poisoning Fomepizole (4-Methylpyrazole) can be used as: A reactant to prepare 4-methyl-1-phenyl-1H-pyrazole by reacting with bromobenzene via N-arylation using a copper catalyst. A starting material for the synthesis of 4-methyl-3(5)-nitropyrazole by nitration. A ligand in the preparation of gallium(III) complex of 4-methylpyrazole as potential antitumor and antiviral agent.

Technology Process of Fomepizole

There total 10 articles about Fomepizole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.52%

: 7554-65-6
4-methyl-1H-pyrazole

Guidance literature:

Reference yield: 84.0%

: 10602-37-6
1,1,3,3-tetraethoxy-2-methyl-propane

: 7554-65-6
4-methyl-1H-pyrazole

Guidance literature:: 1,1,3,3-tetraethoxy-2-methyl-propane; With hydrazinium sulfate; In water; at 80 ℃; for 3h;

With sodium hydroxide; In water; at 3 - 30 ℃; pH=4 - 6;

With sodium hydrogencarbonate; In water; at 27 - 30 ℃; pH=7;