Rosuvastatin methyl ester

Base Information Edit

Chemical Name:Rosuvastatin methyl ester
CAS No.:147118-40-9
Molecular Formula:C23H30FN3O6S
Molecular Weight:495.572
Hs Code.:2935009090
Mol file:147118-40-9.mol

Synonyms:6-Heptenoicacid,7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-,methyl ester, [S-[R*,S*-(E)]]-;

Suppliers and Price of Rosuvastatin methyl ester

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
RosuvastatinMethylEster
100mg
$ 185.00

Medical Isotopes, Inc.
RosuvastatinMethylEster
1 g
$ 2200.00

Matrix Scientific
(3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)-amino]-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoicacid methyl ester95+%
1g
$ 706.00

Matrix Scientific
(3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)-amino]-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoicacid methyl ester95+%
250mg
$ 322.00

Crysdot
Rosuvastatinmethylester 95+%
5g
$ 297.00

Crysdot
Rosuvastatinmethylester 95+%
10g
$ 495.00

Chemenu
(3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)-amino]-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoicacid,methylester 95%
1g
$ 102.00

Chemenu
(3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)-amino]-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoicacid,methylester 95%
10g
$ 468.00

Chemenu
(3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)-amino]-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoicacid,methylester 95%
5g
$ 281.00

AvaChem
Rosuvastatin Methyl Ester
1g
$ 750.00

Total 127 raw suppliers

Chemical Property of Rosuvastatin methyl ester Edit

Chemical Property:

Vapor Pressure:4E-20mmHg at 25°C
Refractive Index:1.575
Boiling Point:692.3 °C at 760 mmHg
PKA:13.33±0.20(Predicted)
Flash Point:372.5 °C
PSA：138.30000
Density:1.313 g/cm³
LogP:3.57090
Storage Temp.:Sealed in dry,Room Temperature
Solubility.:DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

RosuvastatinMethylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Rosuvastatin Methyl Ester is an impurity of Rosuvastatin (R700500) in the pharmaceutical dosage forms under forced degradation conditions.

Technology Process of Rosuvastatin methyl ester

There total 29 articles about Rosuvastatin methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.2%

: 147118-39-6
methyl (3R,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(propan-2-yl)pyrimidin-5-yl]-3-hydroxy-5-oxohept-6-enoate

(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid methyl ester: 147118-40-9
(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid methyl ester

Guidance literature:: methyl (3R,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(propan-2-yl)pyrimidin-5-yl]-3-hydroxy-5-oxohept-6-enoate; With diethyl methoxy borane; In tetrahydrofuran; methanol; at -78 ℃; for 0.5h;

With sodium tetrahydroborate; In tetrahydrofuran; methanol; for 3h;