4-Methylsulphonyl benzaldehyde

Base Information

• Chemical Name: 4-Methylsulphonyl benzaldehyde
• CAS No.: 5398-77-6
• Molecular Formula: C8H8 O3 S
• Molecular Weight: 184.216
• Hs Code.: 29130000
• Mol file: 5398-77-6.mol

Synonyms:Benzaldehyde,p-(methylsulfonyl)- (7CI,8CI); 4-(Methylsulfonyl)benzaldehyde;4-Methanesulfonylbenzaldehyde; Methyl 4-formylphenyl sulfone; NSC 3011;p-(Methylsulfonyl)benzaldehyde

Chemical Property of 4-Methylsulphonyl benzaldehyde

Chemical Property:

• Appearance/Colour: Intermediate product of Veterinary Thiamphenicol
• Vapor Pressure: 6.35E-06mmHg at 25°C
• Melting Point: 155-161 ºC
• Refractive Index: 1.544
• Boiling Point: 378.3°Cat760mmHg
• Flash Point: 242.1°C
• PSA: 59.59000
• Density: 1.289g/cm³
• LogP: 1.98340
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: Chloroform, Methanol

Purity/Quality:

99.9% ^*data from raw suppliers

4-Methylsulfonylbenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 24/25-26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-(Methylsulfonyl)benzaldehyde has been used in the preparation of arylidene-thiazolidinedione derivatives for the treatment of type 2 diabetes.

Technology Process of 4-Methylsulphonyl benzaldehyde

There total 46 articles about 4-Methylsulphonyl benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(1,1-dimethoxy-methyl)-4-methanesulfonyl-benzene (100515-19-3) → para-methanesulfonylbenzaldehyde (5398-77-6)

Guidance literature:

With sulfuric acid; In tetrahydrofuran; for 5h; Ambient temperature;

DOI:10.1021/jo00357a032

Reference yield: 98.0%

4-(Methylthio)benzaldehyde (3446-89-7) → para-methanesulfonylbenzaldehyde (5398-77-6)

Guidance literature:

With sodium hydroxide; 3-chloro-benzenecarboperoxoic acid; at 1 - 3 ℃; for 2h;

DOI:10.1080/00397919408010580

Reference yield: 96.2%

4-fluorobenzaldehyde (459-57-4) + methanesulfonic acid sodium salt (2386-57-4) → para-methanesulfonylbenzaldehyde (5398-77-6)

Guidance literature:

In water; at 65 ℃; for 10.5h; Temperature; Large scale;

upstream raw materials:

1-diacetoxymethyl-4-methanesulfonyl-benzene

4-(methylsulfonyl)benzonitrile

4-(methylsulfonyl)benzyl bromide

sodium methansulfinate

Downstream raw materials:

3-(4-methanesulfonyl-phenyl)-acrylic acid

threo-2-amino-3-hydroxy-3-(4-(methylsulfonyl)phenyl)propanoic acid

benzyl-(4-methanesulfonyl-benzyliden)-amine

2-(4-methanesulfonyl-phenyl)-[1,3]oxathiolane

Refernces

• 1、 -. "Preparation method of p-methylsulfonyl benzaldehyde". Paragraph 0014; 0027-0028; 0032-0034; 0038-0040; 0044.... . Retrieved 2021/07/24.
• 2、 Amri, Nasser,Wirth, Thomas. "Flow Electrosynthesis of Sulfoxides, Sulfones, and Sulfoximines without Supporting Electrolytes". . p. 15961 - 15972. Retrieved 2021/07/20.