Thiophene-2-carbohydrazide

Base Information

• Chemical Name: Thiophene-2-carbohydrazide
• CAS No.: 2361-27-5
• Molecular Formula: C5H6N2OS
• Molecular Weight: 142.181
• Hs Code.: 29349990
• European Community (EC) Number: 219-107-0
• NSC Number: 120045,653
• UNII: W4J3WEF93N
• DSSTox Substance ID: DTXSID80178271
• Nikkaji Number: J170H
• Wikidata: Q72508837
• ChEMBL ID: CHEMBL3091844
• Mol file: 2361-27-5.mol

Synonyms:thiophene-2-carboxylic acid hydrazide

Chemical Property of Thiophene-2-carbohydrazide

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Melting Point: 136-139 °C(lit.)
• Refractive Index: 1.644
• Boiling Point: 260oC at 760mmHg
• PKA: 12.43±0.10(Predicted)
• Flash Point: 117.8oC
• PSA: 83.36000
• Density: 1.335 g/cm³
• LogP: 1.44280
• Storage Temp.: Store at RT.
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 142.02008399
• Heavy Atom Count: 9
• Complexity: 118

Purity/Quality:

99% ^*data from raw suppliers

2-Thiophenecarboxylic acid hydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CSC(=C1)C(=O)NN

Technology Process of Thiophene-2-carbohydrazide

There total 9 articles about Thiophene-2-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-thiophenylcarboxylic acid (527-72-0) → 2-thienylhydrazide (2361-27-5)

Guidance literature:

2-thiophenylcarboxylic acid; With dicyclohexyl-carbodiimide; In acetonitrile; at 0 - 20 ℃;

With benzotriazol-1-ol; In acetonitrile; at 0 - 20 ℃;

With hydrazine hydrate; In acetonitrile; at 0 - 20 ℃; for 5h;

Reference yield: 87.0%

1,3-dicyclohexyl-1-(thiophene-2-carbonyl)urea (1204708-00-8) → 2-thienylhydrazide (2361-27-5)

Guidance literature:

With hydrazine hydrate; In acetonitrile; at 0 - 20 ℃; for 6h;

Reference yield: 86.7%

thiophene-2-carboxylic acid methyl ester (5380-42-7) → 2-thienylhydrazide (2361-27-5)

Guidance literature:

With hydrazine hydrate; In methanol; for 0.0833333h; Microwave irradiation;

DOI:10.1039/c9ra09831c

upstream raw materials:

Ethyl thiophene-2-carboxylate

thiophene-2-carboxylic acid methyl ester

C₁₀H₁₄N₂O₃S

2-thiophenylcarboxylic acid

Downstream raw materials:

5-[2]thienyl-3H-[1,3,4]oxadiazol-2-one

(E)-N'-(benzo[d][1,3]dioxol-5-ylmethylene)thiophene-2-carbohydrazide

thiophene-2-carboxylic acid-[(9-ethyl-carbazol-3-ylmethylene)-hydrazide]

thiophene-2-carboxylic acid cyclohexyLiDenehydrazide

Refernces

• 1、 Kundu, Bidyut Kumar,Pragti,Reena,Mobin, Shaikh M.,Mukhopadhyay, Suman. "Mechanistic and thermodynamic aspects of a pyrene-based fluorescent probe to detect picric acid". . p. 11483 - 11492. Retrieved 2019.
• 2、 -. "Pleuromutilin derivative with 1, 3, 4-oxadiazole side chain and preparation and application thereof". Paragraph 0055-0056; 0070; 0090; 0093; 0095; 0102. . Retrieved 2021/07/24.
• 3、 Gavara, Laurent,Legru, Alice,Verdirosa, Federica,Sevaille, Laurent,Nauton, Lionel,Corsica, Giuseppina,Mercuri, Paola Sandra,Sannio, Filomena,Feller, Georges,Coulon, Rémi,De Luca, Filomena,Cerboni, Giulia,Tanfoni, Silvia,Chelini, Giulia,Galleni, Moreno,Docquier, Jean-Denis,Hernandez, Jean-Fran?ois. "4-Alkyl-1,2,4-triazole-3-thione analogues as metallo-β-lactamase inhibitors". supporting information. . Retrieved 2021/06/15.