Pyridine hydrofluoride

Base Information

• Chemical Name: Pyridine hydrofluoride
• CAS No.: 32001-55-1
• Deprecated CAS: 71398-22-6,374549-75-4,374549-75-4
• Molecular Formula: C5H5N^.HF
• Molecular Weight: 99.1077
• Hs Code.: 29333999
• European Community (EC) Number: 250-889-6,613-082-3
• DSSTox Substance ID: DTXSID3067653
• Mol file: 32001-55-1.mol

Synonyms:Pyridine hydrofluoride;32001-55-1;Hydrogen Fluoride-Pyridine;62778-11-4;Olah's Reagent;Pyridinium fluoride;pyridine;hydrofluoride;Hydrogen fluoride pyridine;Pyridine, hydrofluoride;Hydrogen fluoride-pyridine (70% HF);Pyridine, hydrofluoride (1:1);EINECS 250-889-6;Hydrogen fluoride, pyridine reagent, anhydrous;MFCD00012436;HF.pyridine;Pyridine-hydrofluoride;hydrofluoric acid pyridine;hydrogen fluoride/pyridine;pyridine hydrogen fluoride;C5H5N.FH;DTXSID3067653;C5-H5-N.F-H;AMY39447;BCP24413;AKOS005254489;AKOS005254545;AKOS005254546;AKOS005254547;BP-31048;FT-0602823;FT-0688096;D78350;J-524101;F0001-0956;Hydrogen fluoride pyridine, pyridine ~30 %, hydrogen fluoride ~70 %;71398-22-6

Chemical Property of Pyridine hydrofluoride

Chemical Property:

• Appearance/Colour: clear pale yellow to light brown liquid
• Vapor Pressure: 22.8mmHg at 25°C
• Melting Point: -41.6oC
• Boiling Point: 115.3 °C at 760 mmHg
• Flash Point: 20 °C
• PSA: 12.89000
• Density: 1.1g/mLat 20°C(lit.)
• LogP: 1.61430
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Sensitive.: Moisture Sensitive
• Solubility.: Chloroform
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 99.048427358
• Heavy Atom Count: 7
• Complexity: 30.9

Purity/Quality:

99% ^*data from raw suppliers

Hydrogen fluoride-pyridine (70% HF) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T+, C
• Hazard Codes: T+,C
• Statements: 26/27/28-35-34
• Safety Statements: 26-28-36/37/39-45-27

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC=C1.F
• Uses: Pyridinium Poly(hydrogenfluoride) is used in the synthesis of analogues of antimitotic natural product curacin A. It is also an effective fluorinating agent.

Technology Process of Pyridine hydrofluoride

There total 3 articles about Pyridine hydrofluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pyridine (110-86-1) → pyridine hydrogenfluoride (32001-55-1,62778-11-4)

Guidance literature:

With hydrogen fluoride; at 0 ℃;

DOI:10.1016/j.tet.2012.09.104

Reference yield:

pyridine (110-86-1) + hydrogen fluoride (7664-39-3,12381-92-9,32057-09-3,74835-82-8) → pyridine hydrogenfluoride (32001-55-1,62778-11-4)

Guidance literature:

at 20 ℃; for 1h; Cooling with ice;

Reference yield:

→ 2-bromo-4-fluoro-pentan-3-ol + pyridine hydrogenfluoride (32001-55-1,62778-11-4)

Guidance literature:

upstream raw materials:

pyridine

hydrogen fluoride

Downstream raw materials:

dimethyl 4-fluoro-5-methylphthalate

(C₅(CH₃)5)2ZrF(C₆F₄H)

C₁₅H₂₄N₂*F₃Ge^(1-)*H⁽¹⁺⁾

Refernces

• 1、 Hara, Shoji,Monoi, Miki,Umemura, Ryosuke,Fuse, Chiaki. "IF5-pyridine-HF: Air- and moisture-stable fluorination reagent". . p. 10145 - 10150,6. Retrieved 2020/09/02.