2-Bromo-2-methylpropionyl bromide

Base Information

• Chemical Name: 2-Bromo-2-methylpropionyl bromide
• CAS No.: 20769-85-1
• Molecular Formula: C4H6Br2O
• Molecular Weight: 229.899
• Hs Code.: 29159080
• European Community (EC) Number: 244-017-3
• UNII: 627F9N9DYA
• DSSTox Substance ID: DTXSID7045077
• Nikkaji Number: J93.725H
• Wikidata: Q27263457
• Mol file: 20769-85-1.mol

Synonyms:2-Bromo-2-methylpropionyl bromide;20769-85-1;2-Bromoisobutyryl bromide;2-Bromo-2-methylpropanoyl bromide;Propanoyl bromide, 2-bromo-2-methyl-;BIBB;2-Bromo-2-methylpropionylbromide;alpha-Bromoisobutyryl bromide;2-Bromoisobutyrylbromide;2-Bromo-2-methyl-propionyl bromide;bromoisobutyryl bromide;UNII-627F9N9DYA;627F9N9DYA;.alpha.-Bromoisobutyryl bromide;2-bromo-2-methyl-propanoyl bromide;EINECS 244-017-3;AI3-28200;EC 244-017-3;MFCD00000122;bromoisobutyrylbromide;bromoisobutyroyl bromide;Bromo-isobutyryl bromide;2-bromisobutyryl bromide;2-bromoisobutryl bromide;a-bromoisobutyryl bromide;2-bromo isobutyrylbromide;2-bromoisobutyric bromide;alpha-bromoisobutrylbromide;bromodimethylacetyl bromide;2-bromoisobutanoyl bromide;2-bromo isobutyryl bromide;alpha-bromoisobutyrylbromide;alpha -Bromoisobutyryl bromide;SCHEMBL108911;2-bromoisobutyric acid bromide;2-bromo-2-methylpropionylbromid;DTXSID7045077;YOCIJWAHRAJQFT-UHFFFAOYSA-;2-bromo-2-methyl-propionylbromide;2-bromo-2-methylproprionyl bromide;2-bromo-2-methyl propionyl bromide;alpha-Bromoisobutyryl bromide, 98%;2-Bromo-2-methylpropanoyl bromide #;2-bromanyl-2-methyl-propanoyl bromide;AKOS022568038;AM84723;AS-19151;B0607;FT-0611398;PROPIONYL BROMIDE, 2-BROMO-2-METHYL-;EN300-122693;H11248;A814866;J-508189;Q27263457;F0001-0742;2-Bromoisobutyryl bromide 2-Bromo-2-methylpropionyl bromide

Chemical Property of 2-Bromo-2-methylpropionyl bromide

Chemical Property:

• Appearance/Colour: colourless liquid
• Refractive Index: n20/D 1.507(lit.)
• Boiling Point: 163 °C at 760 mmHg
• Flash Point: 61.8 °C
• PSA: 17.07000
• Density: 1.946 g/cm³
• LogP: 2.08140
• Storage Temp.: Store below +30°C.
• Sensitive.: Moisture Sensitive
• Solubility.: Miscible with acetone and carbon disulfide.
• Water Solubility.: reacts
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 229.87649
• Heavy Atom Count: 7
• Complexity: 87.7

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-2-methylpropionylBromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 22-34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Toxic Gases & Vapors -> Acid Halides
• Canonical SMILES: CC(C)(C(=O)Br)Br
• Description: 2-Bromoisobutyryl Bromide is a kind of bromide being useful in the chemical industry. It is used as an intermediate for the synthesis of pharmaceuticals, agrochemicals, dyes and other organic chemicals1. It can be used as atom transfer radical polymerization (ATRP) initiator for functionalization of hydroxyl groups present on the surface of graphene oxide; to form an N-protected halodienamide which provided fourand five-membered lactams in the presence of copper (I) and a tertiary amine; in preparation of polycaprolactone macroinitiator via reaction with oligomeric caprolactone dio and mesoporous silica nanoparticles with ATRP initiator anchored on the exterior surface2,3. As a initiator precursor, it can also be used for surface modification of Ethylene-vinyl alcohol (EVOH) copolymer films to grow surface-grafted poly-(acrylamide) chains.
• Uses: 2-Bromoisobutyryl bromide is used to prepare N-protected halodienamide, which provides four- and five-membered lactams in the presence of copper(I) and a tertiary amine. Further, it is used as atom transfer radical polymerization(ATRP) initiator for functionalization of hydroxyl groups present on the surface of graphene oxide. It is also used in preparation of polycaprolactone macroinitiators through reaction with oligomeric caprolactone diol and mesoporous silica nanoparticles with ATRP initiator anchored on the exterior surface. α-Bromoisobutyryl bromide has been used:as atom transfer radical polymerization (ATRP) initiator for functionalization of hydroxyl groups present on the surface of graphene oxideto form an N-protected halodienamide which provided four- and five-membered lactams in the presence of copper (I) and a tertiary aminein preparation of polycaprolactone macroinitiator via reaction with oligomeric caprolactone diol and mesoporous silica nanoparticles with ATRP initiator anchored on the exterior surface

Technology Process of 2-Bromo-2-methylpropionyl bromide

There total 6 articles about 2-Bromo-2-methylpropionyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

isobutyryl bromide (2736-37-0) → 2-bromoisobutyric acid bromide (20769-85-1)

Guidance literature:

With bromine; at 100 ℃;

Reference yield:

isobutyryl chloride (79-30-1) → 2-bromoisobutyric acid bromide (20769-85-1)

Guidance literature:

With bromine; at 100 ℃;

Reference yield:

isobutyric Acid (79-31-2) → 2-bromoisobutyric acid bromide (20769-85-1)

Guidance literature:

With phosphorus; bromine;

upstream raw materials:

isobutyryl bromide

isobutyryl chloride

isobutyric Acid

bromine

Downstream raw materials:

3-methylphenyl bromoisobutyrate

2-bromo-2-methyl-N-(4-nitrophenyl)propanamide

1-[(2-bromo-2-methylpropionyl)oxy]-2-propene

2-bromo-2-methyl-N-phenylpropanamide

Refernces

• 1、 -. "Use of 2-phenylmorpholin-5-one derivatives". . . Retrieved 2008/06/13.