5-methoxy-2-nitrophenylacetaldehyde

Base Information

• Chemical Name: 5-methoxy-2-nitrophenylacetaldehyde
• CAS No.: 69111-47-3
• Molecular Formula: C₉H₉NO₄
• Molecular Weight: 195.175
• Mol file: 69111-47-3.mol

Synonyms:5-methoxy-2-nitrophenylacetaldehyde

Chemical Property of 5-methoxy-2-nitrophenylacetaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-methoxy-2-nitrophenylacetaldehyde

There total 3 articles about 5-methoxy-2-nitrophenylacetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-[(E)-2-(5-Methoxy-2-nitro-phenyl)-vinyl]-morpholine (117845-36-0) → 5-methoxy-2-nitrophenylacetaldehyde (69111-47-3)

Guidance literature:

With aq. acid; for 1h; Ambient temperature;

DOI:10.1016/S0040-4039(00)86860-4

Reference yield: 50.0%

methyl nitrite (624-91-9) + 2-vinyl-4-methoxynitrobenzene (126759-31-7) → 5-methoxy-2-nitrophenylacetaldehyde (69111-47-3) + 2,2-dimethoxy-1-(5-methoxy-2-nitrophenyl)ethane (146667-94-9)

Guidance literature:

With oxygen; sodium tetrachloropalladate(II); In methanol; for 24h; Ambient temperature;

Reference yield:

(5-methoxy-2-nitro-phenyl)-pyruvic acid (82204-34-0) → 5-methoxy-2-nitrophenylacetaldehyde (69111-47-3)

Guidance literature:

Multi-step reaction with 2 steps

1: p-toluenesulfonic acid / benzene / Heating

2: 93 percent / aq. acid / 1 h / Ambient temperature

With aq. acid; toluene-4-sulfonic acid; In benzene;

DOI:10.1016/S0040-4039(00)86860-4

upstream raw materials:

methyl nitrite

2-vinyl-4-methoxynitrobenzene

4-[(E)-2-(5-Methoxy-2-nitro-phenyl)-vinyl]-morpholine

(5-methoxy-2-nitro-phenyl)-pyruvic acid

Refernces

• 1、 Stamos, Ioannis K.. "ALDEHYDE-ENAMINES FROM α-OXOCARBOXYLIC ACIDS. A FACILE AND GENERAL ROUTE TO ALDEHYDES VIA DECARBOXYLATION OF α-OXOCARBOXYLIC ACIDS CARRYING β-HYDROGENS". . p. 459 - 462. Retrieved 2007/10/02.