3-Bromo-5-fluorobenzaldehyde

Base Information

• Chemical Name: 3-Bromo-5-fluorobenzaldehyde
• CAS No.: 188813-02-7
• Molecular Formula: C7H4BrFO
• Molecular Weight: 203.011
• Hs Code.: 2913000090
• Mol file: 188813-02-7.mol

Synonyms:3-Fluoro-5-bromobenzaldehyde;

Chemical Property of 3-Bromo-5-fluorobenzaldehyde

Chemical Property:

• Vapor Pressure: 0.064mmHg at 25°C
• Melting Point: 41-43℃
• Refractive Index: 1.585
• Boiling Point: 230.985 °C at 760 mmHg
• Flash Point: 93.497 °C
• PSA: 17.07000
• Density: 1.671 g/cm³
• LogP: 2.40070
• Storage Temp.: Room temperature.
• Sensitive.: Light Sensitive
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Bromo-5-fluorobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Bromo-5-fluorobenzaldehyde is an intermediate in organic syntheses. Reatant in the synthesis of 3,4-diamino-3-cyclobutene-1,2-diones, 9,10-Dihydro-9,10-diboraanthracenes.

Technology Process of 3-Bromo-5-fluorobenzaldehyde

There total 7 articles about 3-Bromo-5-fluorobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1,3-dibromo-5-fluorobenzene (1435-51-4) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 3-bromo-5-fluorobenzaldehyde (188813-02-7)

Guidance literature:

1,3-dibromo-5-fluorobenzene; With n-butyllithium; In diethyl ether; at -78 ℃; for 0.5h;

N,N-dimethyl-formamide; In diethyl ether; at -78 ℃; for 0.5h;

Reference yield: 100.0%

1,3-dibromo-5-fluorobenzene (1435-51-4) + isopropylmagnesium chloride (1068-55-9) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 3-bromo-5-fluorobenzaldehyde (188813-02-7)

Guidance literature:

1,3-dibromo-5-fluorobenzene; isopropylmagnesium chloride; In tetrahydrofuran; at 0 - 20 ℃; for 2.5h;

N,N-dimethyl-formamide; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield: 100.0%

→ 3-bromo-5-fluorobenzaldehyde (188813-02-7) + 3-(1',2'-dihydro-2'-oxospiro[cyclohexane-1,3'-[3H]indol]-5'-yl)-5-fluorobenzonitrile (304875-03-4)

Guidance literature:

upstream raw materials:

5-fluoro-3-hydroxymethylbromobenzene

1,3-dibromo-5-fluorobenzene

isopropylmagnesium chloride

N,N-dimethyl-formamide

Downstream raw materials:

1-(3-bromo-5-fluorophenyl)ethanol

3-fluoro-5-bromobenzaldehyde oxime

1-bromo-3-(difluoromethyl)-5-fluorobenzene

5-fluoro-3-hydroxymethylbromobenzene

Refernces

• 1、 -. "GLUCOSE-SENSITIVE ALBUMIN-BINDING DERIVATIVES". Page/Page column 70; 71. . Retrieved 2019/05/30.
• 2、 Czub, Maja,Durka, Krzysztof,Luliński, Sergiusz,?osiewicz, Justyna,Serwatowski, Janusz,Urban, Mateusz,Wo?niak, Krzysztof. "Synthesis and Transformations of Functionalized Benzosiloxaboroles". . p. 818 - 826. Retrieved 2017/02/15.