(2R,3R,4S,5R)-2-[(1R,2S,3R,4R,6R)-4,6-diamino-3-[(2S,3S,4R,5S,6S)-3-amino-4,5-dihydroxy-6-[(1R)-1-hydroxyethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid

Base Information

• Chemical Name: (2R,3R,4S,5R)-2-[(1R,2S,3R,4R,6R)-4,6-diamino-3-[(2S,3S,4R,5S,6S)-3-amino-4,5-dihydroxy-6-[(1R)-1-hydroxyethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid
• CAS No.: 108321-42-2
• Molecular Formula: C20H40N4O10^.2(H2SO4)
• Molecular Weight: 692.70
• Hs Code.: 29419090
• European Community (EC) Number: 600-864-4
• Mol file: 108321-42-2.mol

Synonyms:G418 Disulfate;108321-42-2;G0349

Chemical Property of (2R,3R,4S,5R)-2-[(1R,2S,3R,4R,6R)-4,6-diamino-3-[(2S,3S,4R,5S,6S)-3-amino-4,5-dihydroxy-6-[(1R)-1-hydroxyethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid

Chemical Property:

• Appearance/Colour: white to off-white powder
• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 1012.1 °C at 760 mmHg
• Flash Point: 565.9 °C
• PSA: 414.35000
• LogP: -2.26520
• Storage Temp.: 2-8°C
• Solubility.: H2O: 50 mg/mL
• Water Solubility.: soluble
• Hydrogen Bond Donor Count: 14
• Hydrogen Bond Acceptor Count: 22
• Rotatable Bond Count: 6
• Exact Mass: 692.20920291
• Heavy Atom Count: 44
• Complexity: 763

Purity/Quality:

98% ^*data from raw suppliers

G418 Sulfate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn,Xi
• Statements: 20/21/22-36/37/38-42/43
• Safety Statements: 22-24/25-36/37-23-36-26-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1C(C(C(C(O1)OC2C(CC(C(C2O)OC3C(C(C(CO3)(C)O)NC)O)N)N)N)O)O)O.OS(=O)(=O)O.OS(=O)(=O)O
• Isomeric SMILES: C[C@H]([C@H]1[C@H]([C@@H]([C@@H]([C@H](O1)O[C@@H]2[C@@H](C[C@H]([C@H]([C@H]2O)O[C@@H]3[C@@H]([C@@H]([C@@](CO3)(C)O)NC)O)N)N)N)O)O)O.OS(=O)(=O)O.OS(=O)(=O)O
• Description: Geneticin (also known as G418, G418 sulfate) is an aminoglycoside antibiotic similar in structure to gentamicin B1, produced by Micromonospora rhodorangea. Geneticin blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells and is commonly used in laboratory research to select genetically engineered cells. Resistance to Geneticin is conferred by the neo gene from Tn5 encoding an aminoglycoside 3'-phosphotransferase, APH 3'II.
• Uses: Geneticin is an aminoglycoside antibiotic similar in structure to gentamicin used for selection and maintenance of prokaryotic and eukaryotic cells. Optimal concentrations for selection and maintenance vary by cell lines. Bacteria and algae require 5 μg/mL or less while animal cells may require 300-500 μg/mL. It is also used to membrane-permeant allosteric effector of hemoglobin therapeutic in cardiovascular diseases and cancer.